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Journal of Cardiovascular Pharmacology, 1989
Hypertension increases cardiovascular morbidity and mortality two- to fourfold. The chief hazards are now atherosclerosis and coronary disease. Risk is proportional to the degree of systolic or diastolic blood pressure elevation at any age, in either sex.
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Risk Factors for Atherosclerosis

1978
Nearly three decades of intensive epidemiological investigation have identified a group of characteristics that predict an individual’s probability of developing clinically manifest disease due to atherosclerosis -- myocardial infarction, sudden death, angina pectoris, stroke, or peripheral vascular disease.
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Cardiorenal Risk Factors

The American Journal of the Medical Sciences, 2010
The chronic renocardiac syndrome, in which chronic kidney disease (CKD) contributes to impairment of cardiac function or structure, is associated with an increased risk of adverse cardiovascular events. The prevalence of CKD in the U.S. population is approximately 11% and has been increasing over time.
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Risk Factors for Osteoarthritis