Results 111 to 120 of about 5,094,715 (305)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Management of Cardiovascular Risk Factors
, 2019 Background: Cardiovascular disease is the most common and yet one of the most preventable causes of death. Control of CVD risk factors is far from optimal in the population and only a minority of patients with CVD risk factors achieved target goals for ...
Althubaity, Mohammad
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Beyond violations : human factors in maintenance failures
, 2007 Human factors are recognised as influencing the performance of workgroups in industrial operations. Surveys and interventions in high-risk industries, notably commercial aviation and power generation, have highlighted the practical implications of a ...
Antonovsky, Ari +1 more
core
Patent Ductus Arteriosus: Perinatal Risk Factors [PDF]
, 2012 Background: Patent Ductus Arteriosus (PDA) is the most common heart disease among the newborn population. Besides prematurity, other factors are believed to play a significant role in this condition.
Nizarali, Z +4 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Background: Cardiovascular diseases (CVDs) are the leading cause of mortality globally and in Poland. This study assessed the prevalence and trends of cardiovascular (CV) risk factors in the Polish population over time.
Jakubiak, Grzegorz K. +18 more
core +1 more source
The Journal of Nutrition, Health and AgingObjectives, setting and participants: We aimed to examine changes in dietary habits, lifestyles (e.g., smoking, physical activity levels, and alcohol intake), anthropometry, other individual health-relevant characteristics, and overall adherence to 2018 ...
Saverio Caini +11 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source