Results 161 to 170 of about 5,094,715 (305)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Risk Factors for Dysfunctional Liver Graft Response: A Case-Control Study. [PDF]

Nurs Health Sci
Cavalcante LP, Neto JC, Alves MBF, da Cunha FAP, Gomes ACB, Barreiro RG, da Silva VM, Lopes MVO.   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Confronting social risk factors for liver disease

, 2019
This presentation will explore the social risk factors for liver disease and how, as health professionals, we can confront these factors, to enable behavioural change.
Mortimore, Gerri
core  

Genetic and environmental risk factors of asthma: a narrative review. [PDF]

Front Immunol
Altynova NK, Lebedeva LP, Abdullayeva MS, Kassymbekova AM, Yergali K, Homaira N, Djansugurova LB.   +6 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Risk factors associated with cancer and metabolic encephalopathy in Alzheimer's disease patients. [PDF]

Front Aging Neurosci
Pham D, O'Brien C, Florez-Bhandari J, Faulstich N, Ojo T, Aloi S, Goodwin R, Roley L, Nathaniel SI, Nathaniel TI.   +9 more
europepmc   +1 more source

Risk factors for asthma [PDF]

Jornal de Pediatria, 1997
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Social risk factors in pediatric gastroenterology. [PDF]

J Pediatr Gastroenterol Nutr
Cruz Herrera E, Partida I, Bien-Aime C, Goldsmith J, Ebel NH, Fiechtner L, Wu AJ, Woo Baidal J.   +7 more
europepmc   +1 more source