Results 151 to 160 of about 4,696,317 (312)
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Stratospheric precursor induces wintertime phase reversal of the “warm Arctic-cold Eurasia” pattern
Nature CommunicationsRapid Arctic warming has reached 2–4 times the global average, contrasting with the cooling trend in mid-high latitude Eurasia during the 1990s–2010s. A notable phenomenon of the “warm Arctic-cold Eurasia” (WACE) pattern is its frequent phase reversal ...
Yijia Zhang +4 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Upper-ocean stratification changes control ENSO amplitude shift under sustained global warming
Nature CommunicationsAs projected by climate models in the high emission scenarios, the El Niño–Southern Oscillation (ENSO) exhibits a non-monotonic amplitude shift. However, its key drivers remain poorly quantified.
Rong-Hua Zhang +9 more
doaj +1 more source
Risk Management Lessons from Madoff Fraud [PDF]
In December 2008, as the nancial and economic crisis continued on its devastating course, a new scandal erupted. After the 1998's failure of Long-Term Capital Management, Madoff's fraud once again discredits the hedge funds industry.
Clauss, Pierre +2 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
CAUSAL RELATIONS BETWEEN NATURAL RISK AND BUSINESS RISK [PDF]
After a period marked by economic and financial crisis, the objectives and the priorities focused on restoring the balances, the correlations and the proportions of macroeconomic policy makers have focused attention to optimizing the relationship between
Danu Marcela-Cornelia
core
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Measuring the Consistency of Phytosanitary Measures [PDF]
The paper presents a model for quantifying quarantine-related phytosanitary measures by combining the two basic components of pest risk assessment, probability of establishment and economic effects, into a single management framework, Iso-Risk. The model
Bigsby, Hugh R.
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source