Results 101 to 110 of about 546,545 (269)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Flood risk mapping [PDF]

open access: yes, 2009
U ovom članku se razmatra metodologija kartiranja plavnih područja, šteta i rizika. Težište je na načinu određivanja sintetičkih funkcija potencijalne štete, koje se korite za definisanje očekivane godišnje štete, kao glavnog parametra za kvantifikovanje rizika od poplava. Metodologija je ilustrovana primerima iz naše prakse.
Jovanović, Miodrag   +2 more
openaire  

Invasive Fascioloides magna and Its Italian “Alcatraz”

open access: yesVeterinary Sciences
Fascioloides magna, an invasive trematode introduced to Europe in the 19th century, persists in two main foci: the Danube basin and La Mandria Natural Park (LMNP) in northern Italy.
Marco Coraglia   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

A Voxel-Based Optimal Path Planning Method for UAV Navigation in Smart Cities

open access: yesISPRS International Journal of Geo-Information
Smart mobility has emerged as a sustainable solution to the challenges of traffic congestion and environmental pollution in cities. Within this concept, Urban Air Mobility (UAM) offers a promising approach to three-dimensional (3D) urban transportation ...
Min Jang, Dohee Kim, Jiyeong Lee
doaj   +1 more source

Risk map development for soil-transmitted helminth infections in Argentina. [PDF]

open access: yesPLoS Negl Trop Dis, 2020
Alvarez Di Fino EM   +4 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Multidimensional Coupling Model for Quantitative Ground Risk Assessment of Urban Low-Altitude Logistics UAVs

open access: yesIEEE Access
This paper proposes a multi-dimensional coupled quantitative model for the ground risk of urban low-altitude logistics drones, integrating public acceptance, to address the difficulty of existing assessment methods in integrating dynamic environmental ...
Hongmei Chen   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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