Results 61 to 70 of about 771,097 (265)

Risk based analysis of RHPP penstock structural integrity

Fracture and Structural Integrity, 2020
Risk based analysis of reverse hydro power plant penstock structural integrity is performed using fracture mechanics parameters. To assess its structural integrity, extensive testing of the full-scale prototype had been performed, including hydrostatic ...
Sneana Kirin, Lazar Jeremic, Aleksandar Sedmak, Igor Martic, Simon Sedmak, Ivana Vucetic, Tamara Golubovic   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A herbicide resistance risk matrix

Crop Protection, 2019
Herbicide resistance is of increasing concern, especially as there is a lack of new modes of action. An assessment of resistance risk has been a key part of the pesticide authorisation process in most European countries since the early 2000's. However, little guidance is provided on how to quantify these risks. The risk matrix described here presents a
Stephen Moss, Lena Ulber, Ingrid den Hoed   +2 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Risk Analysis in Healthcare Organizations: Methodological Framework and Critical Variables

Risk Management and Healthcare Policy, 2021
Giacomo Pascarella,1 Matteo Rossi,2 Emma Montella,3 Arturo Capasso,2 Gianfranco De Feo,1 Gerardo Botti Snr,1 Antonio Nardone,3 Paolo Montuori,3 Maria Triassi,3 Stefania D’Auria,4 Alessandro Morabito5 1Scientific Directorate, Istituto Nazionale Tumori ...
Pascarella G, Rossi M, Montella E, Capasso A, De Feo G, Botti Snr G, Nardone A, Montuori P, Triassi M, D'Auria S, Morabito A   +10 more
doaj  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Application of “WHAT–IF” Analysis in Risk Assessment During Rescue Operations at Traffic Accidents

Science, Engineering and Technology
Technical rescue in traffic accidents represents one of the most dynamic and high-risk interventions for emergency services. This study aimed to apply the WHAT–IF analysis to systematic risk assessment during these operations, with particular focus on ...
Marinko Aleksić, Fuad Klisura, Luka Maljević, Teodora Kovačević   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Artificial Intelligence Approach in Aerospace for Error Mitigation

Aerospace
Many of the reports created at assembly lines, where all components of an aircraft are installed, frequently indicate that errors threaten safety. The proposed methodology in this study evaluates error prediction and risk mitigation to prevent failures ...
Jorge Bautista-Hernández, María Ángeles Martín-Prats   +1 more
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source