Results 181 to 190 of about 2,894,776 (300)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Winner's Curse Free Robust Mendelian Randomization with Summary Data. [PDF]

J Am Stat Assoc
Xie Z, Zhang W, Wang J, Wu C.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

How do we measure data sharing in the biomedical sciences? A measurement systematic review of biomedical data sharing-related knowledge, attitudes and practices across stakeholder groups, data types and geographies. [PDF]

BMJ Open
Maxwell L, Shreedhar P, Gilyan R, Naccache M, Terry RF.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Retraction: Community's perceived high risk of coronavirus infections during early phase of epidemics are significantly influenced by socio-demographic background, in Gondar City, Northwest Ethiopia: A cross-sectional -study. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Bankacılıkta risk yönetimi ve risk ölçüm yöntemleri / Risk management and risk measurement methods in banking

, 2007
Geçmiş yıllarda yaşanan finansal olayların olumsuz etkileri finansal kurumların bankacılık sektöründe karşılaştıkları tüm riskleri ölçebilmek amacıyla modern risk yönetimi yaklaşımlarını kullanmalarının gerekliliğini ortaya koymuştur. Risk yönetimi kriz ortamlarında finansal kayıpları azaltan, karlılığı ise arttıran stratejik bir araç olarak ...
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Deep learning image reconstruction optimizes coronary artery calcium quantification. [PDF]

Front Cardiovasc Med
Zhou T, Liu M, Wu T, Zhang M, Dong J, Ma Z, Li Y, Ba X.   +7 more
europepmc   +1 more source