Results 101 to 110 of about 34,016,939 (394)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Hematology, 2022 Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only curative treatment for myelodysplastic syndromes (MDS), although predicting post-transplant outcomes remains inconclusive.
Haruka Teshigawara-Tanabe +15 more
doaj +1 more source
Topical review: a comprehensive risk model for disordered eating in youth with type 1 diabetes.
Journal of Pediatric Psychology, 2015 OBJECTIVES Provide an updated literature review on prevalence, measurement, and correlates of disordered eating in youth with Type 1 diabetes (T1D), present a novel theoretical risk model (i.e., The Modified Dual Pathway Model) for disordered eating in ...
Claire M. Peterson +2 more
semanticscholar +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: This study aimed to explore the prognostic value of angiogenesis-related genes (ARGs) and their association with immune cell infiltration (ICI) in breast cancer (BC).Methods: Transcriptome data of BC were obtained from the TCGA and GEO ...
Dan Tao +10 more
doaj +1 more source
Risk Measurement, Risk Entropy, and Autonomous Driving Risk Modeling [PDF]
arXiv, 2021 It has been for a long time to use big data of autonomous vehicles for perception, prediction, planning, and control of driving. Naturally, it is increasingly questioned why not using this big data for risk management and actuarial modeling. This article examines the emerging technical difficulties, new ideas, and methods of risk modeling under ...
arxiv
Asymptotic ruin probabilities for a bidimensional renewal risk model
Statistics and Probability Letters, 2015 This paper studies a bidimensional renewal risk model with constant force of interest and heavy-tailed claims. We extend the existing models through allowing arbitrary dependences between each pair of inter-arrival times of the two kinds of insurance ...
Haizhong Yang, Jinzhu Li
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Renal Failure, 2022 Objective To establish a simple model for predicting postoperative acute kidney injury (AKI) requiring renal replacement therapy (RRT) in patients with renal insufficiency (CKD stages 3–4) who underwent cardiac surgery.Methods A total of 330 patients ...
Xijian Wang +3 more
doaj +1 more source
Security Risk Visualization with Semantic Risk Model
Procedia Computer Science, 2016 Understanding and analysing security risks is an essential task when designing and maintaining a systems' security. The first risk analysis should be performed during the system design. Identified risks have to be updated during the lifecycle when security controls are implemented or new threats appear.
Toivonen, Jyri +5 more
openaire +2 more sources