Results 121 to 130 of about 34,016,939 (394)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Discussion of “Mathematical Model for Flood Risk Evaluation” [PDF]

, 1965
H. C. Riggs, Donald M. Thomas, Wenshang Pay   +2 more
openalex   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

PROBAST: A Tool to Assess Risk of Bias and Applicability of Prediction Model Studies: Explanation and Elaboration

Annals of Internal Medicine, 2019
Prediction models in health care aim to predict for an individual whether a particular outcome, such as disease, is present (diagnostic models) or whether it will occur in the future (prognostic models) (16).
K. Moons, R. Wolff, R. Riley, P. Whiting, M. Westwood, G. Collins, J. Reitsma, J. Kleijnen, S. Mallett   +8 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

Genetics in Medicine, 2019
Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk model to incorporate the ...
Andrew Lee, N. Mavaddat, A. Wilcox, A. Cunningham, T. Carver, Simon Hartley, Chantal Babb de Villiers, A. Izquierdo, J. Simard, M. Schmidt, F. Walter, N. Chatterjee, M. García-Closas, M. Tischkowitz, P. Pharoah, D. Easton, A. Antoniou   +16 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2013
Background Tools for the prediction of atrial fibrillation (AF) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark to test novel putative risk factors.
Á. Alonso, B. Krijthe, T. Aspelund, Katherine A. Stepas, M. Pencina, C. Moser, Moritz F. Sinner, Moritz F. Sinner, Moritz F. Sinner, N. Sotoodehnia, J. Fontes, A. Janssens, R. Kronmal, J. Magnani, J. Witteman, A. Chamberlain, S. Lubitz, R. Schnabel, S. Agarwal, D. McManus, D. McManus, D. McManus, P. Ellinor, M. Larson, G. Burke, L. Launer, A. Hofman, Daniel Levy, Daniel Levy, J. Gottdiener, S. Kääb, D. Couper, T. Harris, E. Soliman, B. Stricker, V. Gudnason, S. Heckbert, E. Benjamin   +37 more
semanticscholar   +1 more source

A Contextual Risk Model for the Ellsberg Paradox

, 2011
The Allais and Ellsberg paradoxes show that the expected utility hypothesis and Savage's Sure-Thing Principle are violated in real life decisions. The popular explanation in terms of 'ambiguity aversion' is not completely accepted.
Aerts, Diederik, Sozzo, Sandro
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source