Results 141 to 150 of about 3,028,894 (317)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Comparison of framingham risk model, atherosclerotic cardiovascular disease risk model, and assign risk model in detecting sub-clinical atherosclerosis among DIMAMO residents, Limpopo province, South Africa. [PDF]

Front Cardiovasc Med
Mohlele D, Ntimana CB, Seakamela KP, Choma SSR, Satekge T, Ringane M.   +5 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Budget Impact of the LungFlag™ Predictive Risk Model for Lung Cancer Screening. [PDF]

Pharmacoecon Open
Heuser C, Gould MK, Choman E, Olghi N, Ogale S, Obradovic M.   +5 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A practical tool for predicting outcomes in essential thrombocythemia: Triple A risk model and beyond. [PDF]

Blood Adv
Sönmez Ö, Oyur E, Yönal Hindilerden İ, Hindilerden F, Sönmez M, Karışmaz A, Atlı Z, Soysal T, Eşkazan AE.   +8 more
europepmc   +1 more source

Edge AI Model Deployed for Real-time Detection of Atrial Fibrillation Risk during Sinus Rhythm

H WU, Takumi Sawada, Takafumi Goto, Tatsuya Yoneyama, Tetsuo Sasano, Ken Asada   +5 more
openalex   +2 more sources

Research on Risk Management of Engineering Projects Based on Building Information Model (BIM) Technology [PDF]

Yijie Bian, Qing Liao, Yixin Shi, Xue‐Yang Zhang   +3 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Novel Clinical Nomogram for Predicting Unfavorable Tuberculosis Treatment Outcomes: A Logistic Regression Risk Model. [PDF]

J Epidemiol Glob Health
Xavier SP, Rafael GAP, Gotine ARME, Agostinho MA, Cumaquela G, Rocha ZAJ, Victor A.   +6 more
europepmc   +1 more source