Results 201 to 210 of about 3,028,894 (317)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Clinical significance, prognosis, and risk model of SDHB expression loss and ERBB2 expression in pheochromocytoma and paraganglioma. [PDF]

Endocr Connect
Zhang S, Yang Y, Li W, Shi S.
europepmc   +1 more source

DISTENDER indicators for Round2a (climate and socioeconomic signal) and for: Air Quality and Emissions; Urban Heat Island; Health; Water; Energy; Agroforestry; Sectorial economy; Risk and Vulnerability. Case study: Austria. Global climate model: Ind. Scenario: SSP245.

DISTENDER, ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON UOA, UNIVERSIDADE DE AVEIRO, UNIVERSITAT ZU KOLN, CLIMATE SOLUTIONS UNIPESSOAL LDA, UNIVERSIDAD POLITECNICA DE MADRID, UK CENTRE FOR ECOLOGY & HYDROLOGY   +6 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis. [PDF]

Cell Mol Life Sci
Zhou Y, Chen C, Zuo F, Ding S, Wang H, Xu X, Zhu B, Wu B, Liu C, Yuan T, Ma D, Huang X.   +11 more
europepmc   +1 more source

DISTENDER indicators for Round2a (climate and socioeconomic signal) and for: Air Quality and Emissions; Urban Heat Island; Health; Water; Energy; Agroforestry; Sectorial economy; Risk and Vulnerability. Case study: Austria. Global climate model: MPI-ESM1-2-HR. Scenario: SSP585.

DISTENDER, ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON UOA, UNIVERSIDADE DE AVEIRO, UNIVERSITAT ZU KOLN, CLIMATE SOLUTIONS UNIPESSOAL LDA, UNIVERSIDAD POLITECNICA DE MADRID, UK CENTRE FOR ECOLOGY & HYDROLOGY   +6 more
openalex   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

High-Risk Clinical Characteristics and Risk Model for Unexpected Cervical Cancer Diagnosed After Surgery in Patients with LSIL/HSIL Biopsy. [PDF]

Int J Womens Health
Pan G, Wang W, Sun Z, Chu R, Xue J, Li N.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Establishment and validation of a prognostic risk model based on ADME-related genes in breast cancer. [PDF]

Front Oncol
Yang Y, Yan L, Feng Y, Liu Y, Shi G, Hao J.   +5 more
europepmc   +1 more source