Results 21 to 30 of about 2,942,669 (315)

A novel necroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma

Frontiers in Genetics, 2022
Hepatocellular carcinoma (HCC) is one of the malignant tumors with high mortality and a worse prognosis globally. Necroptosis is a programmed death mediated by receptor-interacting Protein 1 (RIP1), receptor-interacting Protein 1 (RIP3), and Mixed ...
Jianguo Wang, Bingbing Shen, Xinyuan Liu, Jianxin Jiang   +3 more
doaj   +1 more source

A novel prognostic model based on three clinic-related miRNAs for prostate cancer

Frontiers in Surgery, 2022
BackgroundProstate cancer (PCa) is the second most common malignant tumor in men worldwide. MiRNAs have been reported to play significant roles in prognosis prediction for patients with malignant tumors.MethodsThe survival-related miRNAs (sDMIRs) were ...
Ping Che, Ping Che, Shihao Jiang, Weiyang Zhang, Huixuan Zhu, Daorong Hu, Delin Wang   +6 more
doaj   +1 more source

Advancing nearshore and onshore tsunami hazard approximation with machine learning surrogates [PDF]

Natural Hazards and Earth System Sciences
Probabilistic tsunami hazard assessment and probabilistic tsunami risk assessment (PTHA and PTRA) are vital methodologies for computing tsunami risk and prompt measures to mitigate impacts. However, their application across extensive coastlines, spanning
N. Ragu Ramalingam, K. Johnson, M. Pagani, M. Pagani, M. L. V. Martina   +4 more
doaj   +1 more source

Prognostic Implication of Energy Metabolism-Related Gene Signatures in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundLung adenocarcinoma (LUAD) is the major non-small-cell lung cancer pathological subtype with poor prognosis worldwide. Herein, we aimed to build an energy metabolism-associated prognostic gene signature to predict patient survival.MethodsThe ...
Teng Mu, Haoran Li, Xiangnan Li
doaj   +1 more source

Systematic Profiling of Immune Risk Model to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma

Frontiers in Genetics, 2020
Background and PurposeHead and neck squamous carcinoma (HNSCC), characterized by immunosuppression, is a group of highly heterogeneous cancers. Although immunotherapy exerts a promising influence on HNSCC, the response rate remains low and varies in ...
Xingyu Liu, Jiarui Chen, Wei Lu, Zihang Zeng, Jiali Li, Xueping Jiang, Yanping Gao, Yan Gong, Qiuji Wu, Qiuji Wu, Qiuji Wu, Conghua Xie, Conghua Xie, Conghua Xie   +13 more
doaj   +1 more source

Establishment and validation of a prognostic nomogram based on a novel five‐DNA methylation signature for survival in endometrial cancer patients

Cancer Medicine, 2021
Background This study aimed to explore the prognostic role of DNA methylation pattern in endometrial cancer (EC) patients. Methods Differentially methylated genes (DMGs) of EC patients with distinct survival from The Cancer Genome Atlas (TCGA) database ...
Xingchen Li, Fufen Yin, Yuan Fan, Yuan Cheng, Yangyang Dong, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang   +8 more
doaj   +1 more source

RNA N6-Methyladenosine Regulators Contribute to Tumor Immune Microenvironment and Have Clinical Prognostic Impact in Breast Cancer

Frontiers in Genetics, 2022
Purpose: This study aims to reveal the relationship between RNA N6-methyladenosine (m6A) regulators and tumor immune microenvironment (TME) in breast cancer, and to establish a risk model for predicting the occurrence and development of tumors.Patients ...
Lan-Xin Mu, You-Cheng Shao, Lei Wei, Fang-Fang Chen, Jing-Wei Zhang   +4 more
doaj   +1 more source

Risk Models for Advanced Melanoma Patients Under Anti-PD-1 Monotherapy—Ad hoc Analyses of Pooled Data From Two Clinical Trials

Frontiers in Oncology, 2021
Background: The best response and survival outcomes between advanced melanoma patients treated with the anti-PD-1 monotherapy vary greatly, rendering a risk model in need to optimally stratify patients based on their likelihood to benefit from the said ...
Xue Bai, Jie Dai, Caili Li, Chuanliang Cui, Lili Mao, Xiaoting Wei, Xinan Sheng, Zhihong Chi, Xieqiao Yan, Bixia Tang, Bin Lian, Xuan Wang, Li Zhou, Siming Li, Yan Kong, Zhonghui Qi, Huayan Xu, Rong Duan, Jun Guo, Jun Guo, Lu Si   +20 more
doaj   +1 more source

On the Capital Allocation Problem for a New Coherent Risk Measure in Collective Risk Theory

Risks, 2016
In this paper we introduce a new coherent cumulative risk measure on a subclass in the space of càdlàg processes. This new coherent risk measure turns out to be tractable enough within a class of models where the aggregate claims is driven by a ...
Hirbod Assa, Manuel Morales, Hassan Omidi Firouzi   +2 more
doaj   +1 more source

Modeling Interdependent Risks

Risk Analysis, 2007
In an interdependent world the risks faced by any one agent depend not only on its choices but also on those of all others. Expectations about others' choices will influence investments in risk management and the outcome can be suboptimal for everyone. We model this as the Nash equilibrium of a game and give conditions for such a suboptimal equilibrium
Heal, Geoffrey, Kunreuther, Howard
openaire   +4 more sources