Results 81 to 90 of about 6,268,814 (252)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Intertemporal Risk Management Decisions of Farmers under Preference, Market, and Policy Dynamics [PDF]

open access: yes
This paper adapts a generalized expected utility (GEU) maximization model (Epstein and Zin, 1989 and 1991) to examine the intertemporal risk management of wheat producers in the Pacific Northwest. Optimization results based on simulated data indicate the
Du, Wen, Wang, H. Holly
core  

Climate Risk Assessment - Charleston County, South Carolina

open access: yes, 2023
As a result of climate change, flood risk is expected to increase throughout Charleston County. The probability of the 100-year rainfall event, a useful indicator of flood risk, will likely triple by the mid 21st century.
Woodwell Climate Research Center - Risk Program   +2 more
core   +1 more source

From financial scarcity to risk and time preferences: the role of executive functions

open access: yesFrontiers in Psychology
IntroductionUnderstanding how financial scarcity influences intertemporal decision-making is crucial for designing effective poverty-alleviation policies. However, the cognitive mechanisms underlying this relationship remain insufficiently explored. This
Jiaqi Huang, Haibo Zhu
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Evaluating Lotteries, Risks, and Risk-mitigation Programs [PDF]

open access: yes
Two experiments were designed to explore the existence of systematic differences in risk perceptions and risk attitudes between Chinese and U.S. participants.
Fischbeck, Paul, Wang, Mei
core  

Unobserved heterogeneity in farmers’ risk attitudes: linking risk and loss aversion in semi-arid farming systems of Kenya

open access: yesCogent Food & Agriculture
Understanding farmers’ risk preferences is central to designing interventions that enhance resilience in fragile agroecosystems such as semi-arid farming systems.
Amos Tirra   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

HEDGING AND PRODUCTION DECISIONS UNDER A LINEAR MEAN-VARIANCE PREFERENCE FUNCTION [PDF]

open access: yes
A firm model of production and hedging decisions is developed using a mean-variance preference function. Comparative static analysis of the model generates a number of testable hypotheses.
Chavas, Jean-Paul, Pope, Rulon D.
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy