Results 191 to 200 of about 1,481,559 (298)

COMMUNICATION FROM THE COMMISSION Trans-European networks: Towards an integrated approach {SEC(2007) 374}. COM(2007) 135 final, 21.3.2007 [PDF]

, 2007

core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Application of the WHO new vaccine introduction prioritisation and sequencing framework to guide evidence-based vaccine introduction decisions in Iran, 2025-2030. [PDF]

BMJ Open
Fotouhi A, Younesian S, Mousavi SM, Zahraei SM, Mahmoudi S, Fotouhi F, Nojomi M, Alavi M, Zamani O, Sedighi I, Nateghian A, Akbari Sari A, Movahedi M, Gharagozlou M, Mamishi S, Salehi M, Biglari A, Es-Haghi A, Moradi G, Gouya MM.   +19 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis. [PDF]

Metabolomics
Coffey EL, Gomez A, Tate NM, Baker LA, Lulich JP, Furrow E.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Identification of priority areas for cholera control, Cameroon. [PDF]

Bull World Health Organ
Ngomba A, Esso L, Fouda Mbarga N, Kenko I, Defo E, Mandeng N, Tonye TA, Mendjime P, Bilounga C, Choupo L, Douba E, Etoundi GA.   +11 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Bioinspired Spatio-Temporal Cooperative Path Planning for Heterogeneous UAVs Driven by Bi-Level Games: An SSA-MPC Fusion Approach. [PDF]

Biomimetics (Basel)
Yu Y, Le M.
europepmc   +1 more source

National Multisectoral HIV Prevention Strategy 2009-2012:Towards Achieving Tanzania Without HIV [PDF]

, 2009
The United Republic of Tanzania, (URT)
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