Results 271 to 280 of about 7,140,788 (341)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Reducing drug-related harm by triggering proactive outreach. [PDF]

BMJ Open Qual
Campbell L, Fraser B, Beattie M.
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

AI assisted triage of UK patients in mental health care services: a qualitative focus group study of patients' attitudes. [PDF]

BMC Psychiatry
Smith KA, Hamer-Hunt J, Kormilitzin A, Page H, Joyce DW, Cipriani A, CHRONOSIG group*.   +6 more
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Evaluation of trajectory analysis for disease risk assessment: a scoping review. [PDF]

J Am Med Inform Assoc
Pollington F, Denaxas SC, Li K, Thygesen JH, Lyratzopoulos G, White B.   +5 more
europepmc   +1 more source

Improving Healthcare Efficiency and Patient Outcomes Through Proactive Insight to Action: A Sickle Cell Disease Case Example. [PDF]

J Patient Exp
Rubin D, Brooks E, Biblow R, Smith-Whitley K.   +3 more
europepmc   +1 more source

Towards interprofessional medication safety risk management: a qualitative interview study for physicians in primary and secondary care. [PDF]

BMJ Open
Saavalainen A, Sirenius H, Linden-Lahti C, Laukkanen E, Hosia H, Holmström AR.   +5 more
europepmc   +1 more source

Chat, copy, change: prospects and risks of ChatGPT in the teaching and learning process

Mary Joy Cabreza Juntarciego, Regidor G. Gaboy, Ma. Ruby Hiyasmin M. Delos Santos, Luis Collantes   +3 more
openalex   +2 more sources