Results 61 to 70 of about 6,437,662 (327)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Design of post project analysis and risk management processes for r&d projects [PDF]

, 2003
This study has been performed as a project management process improvement project in the R&D Department of a leading white goods manufacturer in Turkey.
Altug Fayda, Sema Nur, Altuğ Fayda, Sema Nur, Iyigun Meydanli, Iffet, İyigün Meydanlı, İffet, Ulusoy, Gunduz, Ulusoy, Gündüz   +5 more
core  

Decision making and risk management in adventure sports coaching [PDF]

, 2013
Adventure sport coaches practice in environments that are dynamic and high in risk, both perceived and actual. The inherent risks associated with these activities, individuals’ responses and the optimal exploitation of both combine to make the processes ...
Abraham A., Ball D., Breakwell G. M., Brevik G., Brown M., Brymer E., Chambers P., Cioffi J., Collins L., Cross N., Csikszentmihalyi M., Effken J. A., English I., Galloway S., Gassner M. E., Gill T., Hattie J., Hunt J., Kahneman D., Klein G., Lupton D., Lyle J., Martin B., Martindale A., McCammon I., McDaniels T., Moxnes P., Nash C., Nonaka I., Polanyi M., Priest S., Schön D., Simon H. A., Stanovich K.E., Stemba B., Thompson C., Tovey H., Wilson R., Wolf B., Wurdinger S. D., Zsambok C. E.   +40 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Review of the strengths and weaknesses of risk matrices [PDF]

, 2014
Risk assessment and risk matrices are powered tools used in risk management and help guide in the process of decision-making in organisations. Nevertheless, risk matrices have their own weaknesses and strengths. This paper provides a critical overview of
Elmontsri, M
core   +2 more sources

The chronometry of risk processing in the human cortex [PDF]

Frontiers in Neuroscience, 2013
The neuroscience of human decision-making has focused on localizing brain activity correlating with decision variables and choice, most commonly using functional MRI (fMRI). Poor temporal resolution means these studies are agnostic in relation to how decisions unfold in time.
Rosalyn J. Moran, Gareth R. Barnes, Raymond J. Dolan, Peter Bossaerts, Peter Bossaerts, Nicholas D. Wright, Mkael Symmonds, Mkael Symmonds   +7 more
openaire   +8 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

High-dimensional GARCH process segmentation with an application to Value-at-Risk [PDF]

, 2020
Models for financial risk often assume that underlying asset returns are stationary. However, there is strong evidence that multivariate financial time series entail changes not only in their within-series dependence structure, but also in the cross ...
Cho, Haeran, Korkas, Karolos
core   +1 more source