Results 271 to 280 of about 17,508,447 (350)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Dual SGLT1/2 inhibition with sotagliflozin: a pharmaceutical breakthrough in heart failure management and cardiometabolic risk reduction. [PDF]

Front Med (Lausanne)
Mansour GK, Hammo SB, Sajid MR.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Challenges in the Choice of Nonstatin Medications for Low-Density Lipoprotein-C Lowering for Cardiovascular Risk Reduction. [PDF]

J Am Heart Assoc
Myerson M, Warden BA, Saseen JJ, Paparodis R.   +3 more
europepmc   +1 more source

Extent of implementation of the <i>Disaster Risk Reduction and Management Act (RA 10121)</i> in the schools of Cabadbaran City, Philippines. [PDF]

Jamba
Daminar NL, Cabonce CB.
europepmc   +1 more source

Awareness and Risk Reduction of Hypertension Among Adults in Ilala and Mkuranga Districts, Tanzania. [PDF]

East Afr Health Res J
Kabanda A, Mbwana HA, Ngowi HA.
europepmc   +1 more source

Evaluating hazard, vulnerability, and capacity through local knowledge for volcano risk reduction. [PDF]

Jamba
Wijayanti P, Noviani R, Koesuma S, Wibowo YA, Nirwansyah AW, Wardhani PI, Hafida SH, Sriyanto S, Andriani A, Muzaqi F.   +9 more
europepmc   +1 more source

Effects of Internet-Based Dementia Risk Reduction Education on Risk and Protective Factor Knowledge, Intentions, and Health Behaviors: Randomized Controlled Trial. [PDF]

J Med Internet Res
Levinson AJ, Ayers S, Clark S, Woodburn R, Schneeberg A, Hadid D, Kates N, Strudwick G, Grad R, Papaioannou A, Dobbins M, Siu H, Duarte D, Saperson K, Marr S, Oliver D, Neil-Sztramko S.   +16 more
europepmc   +1 more source