Results 131 to 140 of about 1,380,859 (329)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Scientific Opinion on the risk to plant health posed by Chrysanthemum stunt viroid for the EU territory, with identification and evaluation of risk reduction options [PDF]

, 2012
EFSA Panel on Plant Health (PLH)
openalex   +1 more source

Operational asset replacement strategy : a real options approach [PDF]

, 2009
This article analyses the problem of replacement by investigating the optimal moment of investment replacement in a given tax environment with a given depreciation policy.
Duque, João, Zambujal, João
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Optimal Allocation of Limited Resources among Discrete Risk Reduction Options [PDF]

, 2015
Michael Todinov
openalex   +1 more source

Effects of Low-cost Offsets on Energy Investment -New Perspectives on REDD- [PDF]

Tropical deforestation is one of the major sources of carbon emissions, but the Kyoto Protocol presently excludes avoiding these specific emissions to fulfill stabilization targets.
Alexander Golub, Jana Szolgayova, Michael Obersteiner, Sabine Fuss   +3 more
core  

Preferences for Exposure Control of Power-Frequency Fields among Lay Opinion Leaders [PDF]

, 1994
The authors report on surveys, differing according to focus on remedial costs, of Pittsburgh-area adults indicating beliefs about possible health effects of electromagnetic fields and the acceptability of options for reducing or eliminating the potential
Adams, Jack, Bostrom, Ann, Morgan, M. Granger, Nair, Indira   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A descriptive survey evaluating the implementation and outcomes of a training session highlighting concepts in antimicrobial management and harm reduction for hospital-based clinicians treating persons who use drugs

Therapeutic Advances in Infectious Disease
Background: People who use drugs (PWUD) are at increased risk for severe infections and face many barriers when completing conventional, typically parenteral antimicrobial treatments.
Michael P. Madaio, Wendy Y. Craig, Amy Eckland, Nichole Moore, Rattanaporn Mahatanan, Colleen M. Kershaw, William Bradford, Ellen Eaton, Alison B. Rapoport, Monica K. Sikka, Hirofumi Yoshida, Kinna Thakarar   +11 more
doaj   +1 more source