Results 121 to 130 of about 3,593,757 (358)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Lifetime Risk of Lower‐Extremity Peripheral Artery Disease Defined by Ankle‐Brachial Index in the United States

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background There are no available lifetime risk estimates of lower‐extremity peripheral artery disease (PAD). Methods and Results Using data from 6 US community‐based cohorts and the vital statistics, we estimated the prevalence and incidence of PAD ...
Kunihiro Matsushita   +11 more
doaj   +1 more source

Left Main Coronary Angioplasty: Assessment of a “Risk Score” to Predict Acute and Long‐Term Outcome [PDF]

open access: green, 1990
Michel Samson   +5 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Scoring Of Post Stroke Pneumonia In Uttaradit Hospital

open access: yesJournal of Multidisciplinary Healthcare, 2019
Nichakarn Leangpanich,1 Yanin Chuphanitsakun,1 Kanyaros Pakaranodom,1 Kunlachat Kerdjarern,1 Watcharapol Poonual2 1Medical Education Center, Faculty of Medicine, Naresuan University, Uttaradit Hospital, Uttaradit 53000, Thailand; 2Medical Education ...
Leangpanich N   +4 more
doaj  

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

Communicating Risk—Coronary Risk Scores

open access: yesJournal of the Royal Statistical Society Series A: Statistics in Society, 2003
SummaryCardiovascular disease, particularly heart attack and stroke, is the major cause of death in adults in Europe. The underlying atherosclerosis which causes cardiovascular disease is difficult to treat or reverse, and this has led to intense interest in strategies to prevent its development.
I. M. Graham, Elizabeth Clavel
openaire   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

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