Results 131 to 140 of about 3,593,757 (358)

IHD risk score. [PDF]

open access: yesCirculation, 1980
H S Rosman, B A Blumenstein
openaire   +3 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

EXPLORING THE SHORT- AND LONG-RUN LINKS FROM BANK COMPETITION TO RISK – RECONCILING CONFLICTING HYPOTHESES? [PDF]

open access: yes, 2013
Using a dataset for the EU-27 covering 1998-2012, this is one of the first studies of banking competition and risk to look at the dynamics of the relation between these variables, to take account of a full 6 year period since the onset of the crisis in ...
Davis, EP, karim, D
core  

Increased risk for malaria in chronically malnourished children under 5 years of age in rural Gambia.

open access: yes, 2002
Malaria and malnutrition cause high morbidity and mortality in rural sub-Saharan Africa. To explore the relationship between nutritional status and malaria, a cohort of Gambian children under 5 years of age was followed weekly during one malaria season ...
Deen, JL, von Seidlein, L, Walraven, GEL
core   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Clinical validity assessment of a breast cancer risk model combining genetic and clinical information [PDF]

open access: yes, 2010
_Background:_ The extent to which common genetic variation can assist in breast cancer (BCa) risk assessment is unclear. We assessed the addition of risk information from a panel of BCa-associated single nucleotide polymorphisms (SNPs) on risk ...
Brian K. Rhees   +5 more
core   +2 more sources

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