Results 141 to 150 of about 11,478,693 (361)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Self-administered osteoporosis risk score

Journal of Mid-Life Health, 2011
Viroj Wiwanitkit
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comparative analysis of the risk assessment of fatal and non-fatal cardiovascular events using SCORE/SCORE2 in patients at the outpatient stage [PDF]

, 2023
Svetlana Lagutina, Anna Pashkova, Ирина Сергеевна Добрынина, E.Yu. Esina, В. И. Шевцова, А. Н. Шевцов, A.N. Shevtsov   +6 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Scoring Of Post Stroke Pneumonia In Uttaradit Hospital

Journal of Multidisciplinary Healthcare, 2019
Nichakarn Leangpanich,1 Yanin Chuphanitsakun,1 Kanyaros Pakaranodom,1 Kunlachat Kerdjarern,1 Watcharapol Poonual2 1Medical Education Center, Faculty of Medicine, Naresuan University, Uttaradit Hospital, Uttaradit 53000, Thailand; 2Medical Education ...
Leangpanich N, Chuphanitsakun Y, Pakaranodom K, Kerdjarern K, Poonual W   +4 more
doaj  

Almanac 2012: Cardiovascular risk scores

Archivos de Cardiología de México, 2013
Global risk scores use individual level information on non-modifiable riskfactors(suchasage,sex,ethnicityandfamilyhistory) and modifiable risk factors (such as smoking statusand blood pressure) to predict an individual’s absolute riskof an adverse event over a specified period of time in thefuture. Cardiovascular risk scores have two major uses inpractice.
openaire   +2 more sources

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes [PDF]

, 2008
James B. Meigs, Peter Shrader, Lisa Sullivan, Jarred B. McAteer, Caroline S. Fox, Josée Dupuis, Alisa K. Manning, José C. Florez, Peter W.F. Wilson, Ralph B. D’Agostino, L. Adrienne Cupples   +10 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source