Results 191 to 200 of about 11,478,693 (361)

Supplementary Figure 1 from Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry

, 2023
Raymond W. Hughley, Marco Matejcic, Ziwei Song, Xin Sheng, Peggy Wan, Lucy Xia, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Alexander Lubmawa, Vicky Kiddu, Frank Asiimwe, Colline Amanya, George Mutema, Kuteesa Job, Mbaaga K. Ssebakumba, Sue A. Ingles, Ann S. Hamilton, Fergus J. Couch, Stephen Watya, David V. Conti, Burcu F. Darst, Christopher A. Haiman   +22 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Glioblastoma Prognosis and Therapeutic Response Predicted by a Cancer-Associated Fibroblasts Risk Score. [PDF]

Mediators Inflamm
Zhou H, Yang X, Zhao W, Huang Y, Zhang Z, Jiang J, Jiang X, Ren B, Yang K, Jinhui L.   +9 more
europepmc   +1 more source

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.

American Journal of Human Genetics, 2020
Minta Thomas, Lori C. Sakoda, M. Hoffmeister, E. Rosenthal, Jeffrey-K Lee, F. V. van Duijnhoven, E. Platz, A. Wu, C. Dampier, A. de la Chapelle, A. Wolk, A. Joshi, A. Burnett-Hartman, A. Gsur, A. Lindblom, A. Castells, Aung Ko Win, B. Namjou, B. van Guelpen, C. Tangen, Qianchuan He, Christopher I. Li, C. Schafmayer, C. Joshu, C. Ulrich, D. Bishop, D. Buchanan, D. Schaid, David A. Drew, D. Muller, D. Duggan, D. Crosslin, D. Albanes, E. Giovannucci, Eric Larson, Flora Qu, F. Mentch, G. Giles, H. Hakonarson, H. Hampel, I. Stanaway, J. Figueiredo, J. Huyghe, J. Minnier, J. Chang-Claude, J. Hampe, J. Harley, K. Visvanathan, Keith R Curtis, K. Offit, Li Li, L. Le Marchand, L. Vodickova, M. Gunter, M. Jenkins, M. Slattery, M. Lemire, M. Woods, M. Song, N. Murphy, N. Lindor, O. Dikilitas, P. Pharoah, P. Campbell, P. Newcomb, R. Milne, R. MacInnis, S. Castellví-Bel, S. Ogino, S. Berndt, S. Bézieau, S. Thibodeau, S. Gallinger, Syed H Zaidi, T. Harrison, T. Keku, T. Hudson, Veronika Vymetálková, V. Moreno, V. Martín, V. Arndt, Wei-Qi Wei, W. Chung, Yu-Ru Su, R. Hayes, E. White, P. Vodicka, G. Casey, S. Gruber, R. Schoen, A. Chan, J. Potter, H. Brenner, G. Jarvik, D. Corley, U. Peters, L. Hsu   +96 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Haematuria cancer risk score as a predictor of muscle-invasive bladder cancer. [PDF]

BJUI Compass
Turan S, Gezmis CT, Cilesiz NC, Uzut M, Satılmısoglu M, Ergul RB, Balcı MBC.   +6 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Risk Scores–Medical Derivatives

Journal of the American College of Cardiology, 2018
openaire   +2 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source