Results 221 to 230 of about 11,478,693 (361)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome

Antonia Kolovos, Ayub Qassim, Henry Marshall, Thi Nguyen, Joshua M. Schmidt, Mark Hassall, Victoria Tang, Giorgina Maxwell, John Landers, Richard Mills, Stewart Lake, Stuart L. Graham, Angela Schulz, Anna Galanopoulos, Robert J. Casson, Ivan Goldberg, Michael Coote, Stephen Best, Jed Lusthaus, Paul R. Healey, Leslie Burnett, Marc Töteberg‐Harms, Erin A. Boese, Andrew Pouw, Puya Gharahkhani, Todd E. Scheetz, Alex W. Hewitt, Stuart MacGregor, Owen M. Siggs, Emmanuelle Souzeau, John H. Fingert, Jamie E. Craig   +31 more
openalex   +2 more sources

Risk Score for the Development of Veno-Occlusive Disease after Allogeneic Hematopoietic Cell Transplant [PDF]

, 2018
Christopher Strouse, Ying Zhang, Mei‐Jie Zhang, Alyssa DiGilio, Marcelo C. Pasquini, Mary M. Horowitz, Stephanie J. Lee, Vincent T. Ho, Muthalagu Ramanathan, Wichai Chinratanalab, Alison W. Loren, Linda J. Burns, Andrew Artz, Kathleen F. Villa, Wael Saber   +14 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Development of a risk score for colorectal cancer screening. [PDF]

Gastroenterol Hepatol Bed Bench
Maserat E, Sadeghi A, Ketabi Moghadam P, Pourhoseingholi MA.   +3 more
europepmc   +1 more source

Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project.

European Heart Journal, 2003
R. M. Conroy, K. Pyörälä, A. P. Fitzgerald, S. Sans, A. Menotti, G. De Backer, D. De Bacquer, P. Ducimetière, P. Jousilahti, U. Keil, I. Njølstad, R. G. Oganov, T. Thomsen, H. Tunstall-Pedoe, A. Tverdal, H. Wedel, P. Whincup, L. Wilhelmsen, I. M. Graham, I. M. Graham   +19 more
semanticscholar   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Polygenic risk score predicts pathologically confirmed cerebral amyloid angiopathy. [PDF]

Alzheimers Dement
Pyun JM, Park YH, Kim S, Nho K, Alzheimer's Disease Neuroimaging Initiative.   +4 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source