Results 241 to 250 of about 11,478,693 (361)

The Genetic Risk Score with Variants at PDGFs  and PDGFRB    for the Risk of Major Cardiovascular Adverse Events in Patients with Coronary Artery Disease [PDF]

Xiaojuan Xu, Wen Li, Fangyuan Liu, Changying Chen, Hankun Xie, Feifan Wang, Xu Han, Qian Zhuang, Xianghai Zhao, Junxiang Sun, Yunjie Yin, Pengfei Wei, Yan Chen, Chong Shen, Song Yang   +14 more
openalex   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Recommendations for responsible use of population descriptors in polygenic risk score development. [PDF]

Nat Genet
Smith JL, Adebamowo CA, Adebamowo SN, Darst BF, Fullerton SM, Gogarten SM, Hamed ME, Hirbo JB, Hysong MR, Johar AS, Khan AT, Kullo IJ, Konigsberg IR, Kraft P, Lange LA, Li Y, Martin AR, Nelson SC, Choudhury A, Ramsay M, Cobran EK, Schaid DJ, Sharma J, Wang Y, Wojcik GL, Polygenic Risk Methods Development (PRIMED) Consortium, Sun Q.   +26 more
europepmc   +1 more source

Development and validation of a 5-year risk model using mammogram risk scores generated from screening digital breast tomosynthesis [PDF]

Shu Jiang, Debbie L. Bennett, Graham A. Colditz   +2 more
openalex   +1 more source

Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED.

Journal of the American Medical Association (JAMA), 2016
R. Zemek, N. Barrowman, S. Freedman, J. Gravel, I. Gagnon, Candice McGahern, M. Aglipay, G. Sangha, K. Boutis, Darcy L Beer, W. Craig, Emma Burns, K. Farion, A. Mikrogianakis, K. Barlow, A. Dubrovsky, W. Meeuwisse, G. Gioia, W. Meehan, M. Beauchamp, Yael Kamil, A. Grool, B. Hoshizaki, P. Anderson, B. Brooks, K. Yeates, M. Vassilyadi, T. Klassen, M. Keightley, Lawrence Richer, C. DeMatteo, M. Osmond   +31 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A Prospective Study to Assess the Diagnostic Efficacy of Laboratory Risk Indicator for Necrotising Fascitis (LRINEC) Scoring System in Patients with Soft Tissue Infection [PDF]

B. Santhi, Naveen Shamnur
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Risk Score Development to Predict Postpartum Cardiovascular Disease Incorporating Pregnancy and Nonpregnancy Factors: A Canada-Wide Study. [PDF]

JACC Adv
Alcantara M, Shapiro GD, Platt RW, Abrahamowicz M, Ray JG, Ukah UV, Dayan N.   +6 more
europepmc   +1 more source