Results 301 to 310 of about 11,478,693 (361)

Polygenic Risk Scores

Current Protocols, 2021
AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Michael D, Osterman, Tyler G, Kinzy, Jessica N Cooke, Bailey   +2 more
openaire   +2 more sources

Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events.

Journal of the American Medical Association (JAMA), 2023
Importance Coronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), but no prior studies have directly compared these markers in the same cohorts ...
S. Khan, W. Post, Xiuqing Guo, Jingyi Tan, F. Zhu, D. Bos, B. Sedaghati-khayat, Jeroen van Rooij, A. Aday, N. Allen, M. Bos, A. Uitterlinden, M. Budoff, D. Lloyd-Jones, J. Mosley, J. Rotter, P. Greenland, M. Kavousi   +17 more
semanticscholar   +1 more source

New-onset atrial fibrillation prediction: the HARMS2-AF risk score.

European Heart Journal, 2023
AIMS Lifestyle risk factors are a modifiable target in atrial fibrillation (AF) management. The relative contribution of individual lifestyle risk factors to AF development has not been described.
L. Segan, R. Canovas, S. Nanayakkara, D. Chieng, S. Prabhu, A. Voskoboinik, H. Sugumar, L. Ling, Geoffrey Lee, J. Morton, A. LaGerche, D. Kaye, P. Sanders, J. Kalman, P. Kistler   +14 more
semanticscholar   +1 more source

Distal Pancreatectomy Fistula Risk Score (D-FRS)

Annals of Surgery, 2022
Objective: To develop 2 distinct preoperative and intraoperative risk scores to predict postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) to improve preventive and mitigation strategies, respectively.
M. de Pastena, E. V. van Bodegraven, T. Mungroop, F. Vissers, L. Jones, G. Marchegiani, A. Balduzzi, S. Klompmaker, S. Paiella, Shazad Tavakoli Rad, B. Groot Koerkamp, C. V. van Eijck, O. Busch, I. D. de Hingh, M. Luyer, Caleb W. Barnhill, T. Seykora, Trudeau Maxwell T, T. de Rooij, M. Tuveri, G. Malleo, A. Esposito, L. Landoni, L. Casetti, A. Alseidi, R. Salvia, E. Steyerberg, M. Abu Hilal, C. Vollmer, M. Besselink, C. Bassi   +30 more
semanticscholar   +1 more source

Genetic Risk Scores

Current Protocols in Human Genetics, 2016
AbstractThe generation of genome‐wide variation data has become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Jessica N, Cooke Bailey, Robert P, Igo
openaire   +2 more sources

Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score

Thrombosis and Haemostasis, 2021
Background Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.
M. D. de Winter, J. Dorresteijn, W. Ageno, C. Ay, J. Beyer-Westendorf, M. Coppens, F. Klok, F. Moustafa, Nicoletta Riva, P. R. Ruiz Artacho, T. Vanassche, M. Nijkeuter   +11 more
semanticscholar   +1 more source

ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study

Gut, 2020
Objectives Existing scores are not accurate at predicting mortality in upper (UGIB) and lower (LGIB) gastrointestinal bleeding. We aimed to develop and validate a new pre-endoscopy score for predicting mortality in both UGIB and LGIB.
S. Laursen, K. Oakland, L. Laine, Vered Bieber, R. Marmo, E. Redondo-Cerezo, H. Dalton, Jeffrey Ngu, M. Schultz, M. Soncini, I. Gralnek, V. Jairath, I. Murray, A. Stanley   +13 more
semanticscholar   +1 more source

Polygenic Risk Scores

2022
Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette, Tybjærg-hansen, Anne   +1 more
openaire   +2 more sources