Results 31 to 40 of about 3,593,757 (358)
Current Protocols in Human Genetics, 2019 AbstractGenome‐wide variation data with millions of genetic markers have become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Robert P, Igo +2 more
openaire +3 more sources
Polygenic risk scores in epilepsy
Medizinische Genetik, 2022 Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
openaire +3 more sources
Characterization of m6A-related lncRNA signature in neuroblastoma
Frontiers in Pediatrics, 2022 N6-methyladenosine (m6A) constitutes one of the most common modifications in mRNA, rRNA, tRNA, microRNA, and long-chain noncoding RNA. The influence of modifications of m6A on the stability of RNA depends upon the expression of methyltransferase (“writer”
Liming Li +5 more
doaj +1 more source
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor–Positive Breast Cancer [PDF]
, 2018 Introduction Early stage estrogen receptor (ER)-positive breast cancer may be treated with chemotherapy in addition to hormone therapy. Currently available molecular signatures assess the risk of recurrence and the benefit of chemotherapy; however ...
Badve, Sunil S. +2 more
core +1 more source
A polygenic risk score for multiple myeloma risk prediction [PDF]
European Journal of Human Genetics, 2021 AbstractThere is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach
Charles Dumontet +41 more
openaire +11 more sources
Individualized Angiotensin‐Converting Enzyme (ACE)‐Inhibitor Therapy in Stable Coronary Artery Disease Based on Clinical and Pharmacogenetic Determinants: The PERindopril GENEtic (PERGENE) Risk Model [PDF]
, 2016 Patients with stable coronary artery disease (CAD) constitute a heterogeneous group in which the treatment benefits by angiotensin-converting enzyme (ACE)-inhibitor therapy vary between individuals.
Akkerhuis, KM +14 more
core +1 more source
Polygenic Risk Score Prediction for Endometriosis [PDF]
Frontiers in Reproductive Health, 2021 Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization. Clinical tools to better identify candidates for laparoscopy-guided diagnosis are urgently needed. Since endometriosis has a strong genetic component, there is a growing interest in using
Kirstine Kloeve-Mogensen +15 more
openaire +8 more sources
Frontiers in Genetics, 2022 Background: The mechanism of copper-induced cell death, which is called cuproptosis, has recently been clarified. However, the integrated role of cuproptosis-related genes in hepatocellular carcinoma (HCC) and its relationship with immune characteristics
Jie Fu +9 more
doaj +1 more source
Frontiers in Genetics, 2022 Purpose: Stomach adenocarcinoma (STAD) is one of the common cancers globally. Cuproptosis is a newly identified cell death pattern. The role of cuproptosis-associated lncRNAs in STAD is unknown.Methods: STAD patient data from TCGA were used to identify ...
Wei Yu +5 more
doaj +1 more source
Oncologic Outcomes of Radical Prostatectomy and Prognostic Stratification in Patients with Clinically Locally Advanced Prostate Cancer [PDF]
, 2017 Oncologic outcomes of radical prostatectomy in 106 patients with clinically locally advanced prostate cancer were demonstrated. The mean follow-up was 50.6 (12-129) months.
Banas, O. (Oleksandr) +6 more
core +2 more sources