Results 131 to 140 of about 1,943,477 (294)

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

The relationship between university student help-seeking intentions and well-being outcomes

Frontiers in Psychiatry
University represents a time of both great uncertainty and change as well as a time of opportunity and learning. University students represent a population both at a higher risk of experiencing poor mental health and diagnosis and a population with ...
Melinda McCabe, Melinda McCabe, Michelle Byrne, Michelle Byrne, Judith Gullifer, Judith Gullifer, Kim Cornish, Kim Cornish   +7 more
doaj   +1 more source

Does Risk Seeking Drive Asset Prices? A stochastic dominance analysis of aggregate investor preferences [PDF]

We investigate whether risk seeking or non-concave utility functions can help to explainthe cross-sectional pattern of stock returns. For this purpose, we analyze the stochasticdominance efficiency classification of the value-weighted market portfolio ...
Levy, H., Post, G.T.
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Understanding the help-seeking behaviours of women at risk of postnatal depression

Proceedings of Singapore Healthcare
Background: Postnatal depression, which affects between 10 and 25% of women worldwide, is a major public health problem. However, studies have shown that patients with postnatal depression engage poorly with treatment.
Junpei Elizabeth Siak, Biwen Jemie Wang, Tze-Ern Chua, Ying Chia Ch’ng, Helen Chen   +4 more
doaj   +1 more source

The moderating role of legal emotions in the relationship between sensation seeking and risk-taking behaviors among college students

Frontiers in Psychology
The dual-system model proposes that asynchronous maturation of the socioemotional and cognitive control systems underlies the high incidence of adolescent risk-taking.
Zhiqiang Wang, Min Zhang, Shuhui Xu
doaj   +1 more source

Political Intergenerational Risk Sharing [PDF]

TIn a stochastic two-period OLG model, featuring an aggregate shock to the economy, ex-ante optimality requires intergenerational risk sharing. We compare the level of time-consistent intergenerational risk sharing chosen by a benevolent government and ...
Marcello D'Amato, Vincenzo Galasso
core  

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source