Results 111 to 120 of about 15,035,436 (335)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Almost Risking It All

Cubic Journal, 2021
This paper provides an argument against understanding risk-taking in design education as something ideally in need of only being calculable and formalisable.
Bo Allesøe Christensen, Peter Vistisen, Thessa Jensen   +2 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Perceptions of Effectiveness of School Counselors with Former Graduates in a TRIO College Program [PDF]

, 2016
The context and variables that affect at-risk students are constantly changing. It is imperative that school counselors understand the risk factors for students and the cultural and social contexts the individual lives within.
Colton, Emily, Cronin, Sarah, Ohrtman, Marguerite, Dr., Thuen, Marin, Torgerson, Erik   +4 more
core   +1 more source

Dynamic Conservation in Risk Society: A Case Study of COVID-19 Pandemic Risk in Kashan Qanat Irrigated Agriculture. [PDF]

Front Public Health, 2022
Manian MA, Khoshbakht K, Mahmoudi H, Liaghati H.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

EXTREMALIZATION AMONG YOUTH: OPPORTUNITY OR REALITY

Вестник Северо-Кавказского федерального университета, 2022
The article investigates the problem of the spread of extremism among young people. In modern Russian society young people have become a group of social risk, teetering on the brink of social exclusion.
Evgeniy V. Lukyantsev
doaj  

COVID-19 smart surveillance: Examination of Knowledge of Apps and mobile thermometer detectors (MTDs) in a high-risk society. [PDF]

Digit Health, 2022
Sayibu M, Chu J, Tosin Yinka A, Rufai OH, Shahani R, Jin MA.   +5 more
europepmc   +1 more source

Risk-sharing in Rural Pakistan [PDF]

Risk-sharing is a fundamental form of economic behaviour. It can occur through formal insurance markets, informal family arrangements, community support, legal institutions (such as bankruptcy), or government tax-transfer programmes.
Syeda Fizza Gillani
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source