Results 101 to 110 of about 6,072,042 (301)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comprehensive management of medulloblastoma based on revised molecular risk stratification

Chinese Journal of Contemporary Neurology and Neurosurgery
Medulloblastoma is the most common malignant central nervous system tumor in children. The current treatment approach primarily consists of surgery combined with adjuvant radiotherapy and chemotherapy.
LIU Hai-long, FENG Zhao-yang, QIU Xiao-guang   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Sudden Cardiac Death Risk Stratification and Prevention in Chagas Disease: A Non-systematic Review of the Literature

Arrhythmia & Electrophysiology Review, 2020
Roberto Keegan, Cynthia Yeung, Adrian Baranchuk   +2 more
doaj   +1 more source

Occupational benzene exposure and the risk of chronic myeloid leukemia: a meta-analysis of cohort studies incorporating study quality dimensions [PDF]

, 2012
OBJECTIVE We documented previously that if study quality is accounted for, evidence from occupational cohort studies on benzene supports a possible association with some lymphoma subtypes, in particular multiple myeloma, and acute and chronic lymphocytic
Vlaanderen, J.J., Dep IRAS, Vermeulen, R., Lan, Q., Rothman, N., Risk Assessment of Toxic and Immunomodulatory Agents, Kromhout, H.   +6 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Biochemical parameters and markers of preclinical pathology of carotid artery wall in patients with different levels of cardiovascular risk by the ESH/ESC scale (2003, 2007)

Кардиоваскулярная терапия и профилактика, 1970
Aim. To study the levels of biochemical markers of cardiovascular risk (CVR) and the ultrasound-assessed target organ damage (TOD), such as intima-media thickness (IMT), atherosclerotic plaques (AP) in carotid arteries (CA), and left ventricular ...
S. Zh. Urazalina, A. N. Rogoza, T. V. Balakhonova, Yu. A. Karpov, V. V. Kukharchuk, S. A. Boytsov   +5 more
doaj  

Risk stratification of older patients [PDF]

American Journal of Hypertension, 2002
Cardiovascular disease is a growing global health threat due in part to demographic shifts, in particular the growing elderly population in which cardiovascular disease is highly likely to develop. Older individuals have numerous coexisting conditions that contribute to increased risk for morbidity and mortality.
openaire   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results

, 2014
Background: Risk stratification processes for patients with possible acute coronary syndrome (ACS) recommend the use of serial sensitive troponin testing over at least 6. h. Troponin assays vary in their analytical performance.
Greenslade, J., Cullen, Louise, Tate, J., Than, M., Lamanna, A., Brown, A. F. T., Cullen, L., Tate, Jillian, Than, Martin, Pretorius, C., Ungerer, Jacobus, Chu, Kevin, Pretorius, Carel, Parsonage, W. A., Parsonage, William, Greenslade, Jaimi, Hammett, C. J., Chu, K., Lamanna, Arvin, Ungerer, J. P. J., Hammett, Christopher, Brown, Anthony   +21 more
core   +1 more source