Results 131 to 140 of about 831,042 (309)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Diagnostic performance of ACR-TIRADS, Korean TIRADS, and American Thyroid Association guidelines for risk stratification of thyroid nodules: a prospective study

, 2022
Mohammad Behbahaninia, Mehrdad Nabahati, Zoleika Moazezi, Rahele Mehraeen, Hoda Shirafkan   +4 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Acute heart failure: definition, risk stratification, classification, formulation ot the diagnosis [PDF]

, 2020
В. Н. Хирманов, Elena F Pavlysh   +1 more
openalex   +1 more source

Causal representation learning for disease risk stratification in multi-ethnic populations using real-world Biobank Cohorts [PDF]

, 2022
Janet Idusiye Mosugu
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Identifying Risk Stratification Associated With a Cancer for Overall Survival by Deep Learning-Based CoxPH [PDF]

, 2019
Cheng‐Hong Yang, Sin‐Hua Moi, Fu Ou‐Yang, Li‐Yeh Chuang, Ming‐Feng Hou, Yu‐Da Lin   +5 more
openalex   +1 more source

Evaluating the Diagnostic Gap in Risk Stratification for Sudden Cardiac Death [PDF]

, 2020
Leonardo Tamariz, Douglas Conway, Rua Mansi, Lea K. Davis, Robert J. Myerburg, Jeffrey J. Goldberger   +5 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Perioperative risk stratification in patients undergoing multi-resection surgeries. Is ASA classification sufficient?

Медицина неотложных состояний
Background. As of today, there are no protocols for managing surgical patients with comorbidities. Therefore, the issue of perioperative management of high-risk surgical patients is very relevant, holds significant importance for practical medicine, and ...
V.V. Yevsieieva, V.I. Cherniy, O.I. Plehutsa, Yu.B. Lisun, S.A. Sheptukha   +4 more
doaj   +1 more source