Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez +15 more
wiley +1 more source
Early Risk Assessment Model for ICA Timing Strategy in Unstable Angina Patients Using Multi-Modal Machine Learning [PDF]
arXivBackground: Invasive coronary arteriography (ICA) is recognized as the gold standard for diagnosing cardiovascular diseases, including unstable angina (UA). The challenge lies in determining the optimal timing for ICA in UA patients, balancing the need for revascularization in high-risk patients against the potential complications in low-risk ones ...
arxiv
Risk Stratification for Sudden Cardiac Death In Patients With Non-ischemic Dilated Cardiomyopathy [PDF]
, 2005 Non ischemic dilated cardiomyopathy (NIDCM) is a disorder of myocardium. It has varying etiologies. Albeit the varying etiologies of this heart muscle disorder, it presents with symptoms of heart failure, and rarely as sudden cardiac death (SCD ...
Ghosh, Joydeep +3 more
core +1 more source
Prediction Model for 30-day Outcomes Among Emergency Department Patients with Lower Gastrointestinal Bleeding [PDF]
, 2020 Introduction: There are currently no robust tools available for risk stratification of emergency department (ED) patients with lower gastrointestinal bleed (LGIB).
Leafloor, Cameron +3 more
core
Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care
Annals of Clinical and Translational Neurology, EarlyView.Abstract Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow‐up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power – all of
Justin M. Leach +3 more
wiley +1 more source
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan
Pediatrics and Neonatology, 2020 Backgorund: Hepatoblastoma is the most common primary liver malignancy in young children. Methods: To identify predictors of the clinical outcomes of hepatoblastoma, we retrospectively reviewed the medical records of 45 children with hepatoblastoma in ...
Wei-Yun Hsu +9 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg +7 more
wiley +1 more source
Deep learning-based identification of patients at increased risk of cancer using routine laboratory markers [PDF]
arXivEarly screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to determine the screening method and frequency, primarily to optimize resource allocation by targeting screening ...
arxiv
Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction [PDF]
, 1999 E. Magnus Ohman +10 more
openalex +1 more source