Results 81 to 90 of about 8,596,167 (260)
Standardized Patient Case Using the HEEADSSS Model for an Adolescent Interview
MedEdPORTAL, 2008 Introduction This resource is a standardized patient (SP) case for medical student education in pediatrics. Within a 15-20 minute time frame, the students are asked to interview a female adolescent using the HEEADSSS (Home environment, Education and ...
Janice Hanson +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Limited Liability, Asymmetric Taxation, and Risk Taking - Why Partial Tax Neutralities can be Harmful [PDF]
We examine the combined effects of asymmetric taxation and limited liability on optimal risk taking of investors. Given an optimal risk level in the pre-tax case under full liability, loss-offset restrictions reduce, and limited liability enhances the ...
Rainer Niemann, Ralf Ewert
core
The baby effect and young male syndrome : social influences on cooperative risk-taking in women and men [PDF]
Parental investment theory predicts differences in risk-taking for females and males as a consequence of reproductive context, with females attempting to reduce risks in relation to their own offspring (here called the baby effect) and males taking more ...
Hills, Thomas Trenholm, Fischer, Dominic
core +1 more source
Journal of Management and Business EducationInnovative firms may react to the swift shift in the business landscape by developing new competencies that allow them to attain an improved outcome. Earlier studies have stressed that entrepreneurial orientation is an essential component for business
Aram H. Massoudi
doaj +1 more source
Evolutionary Psychology, 2015 Inequality has been associated with risk-taking at the societal level. However, this relationship has not been directly investigated at the individual level.
Sandeep Mishra +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Interim Rank, Risk Taking and Performance in Dynamic Tournaments [PDF]
Little is known about the effects of revealing information on relative performance during a dynamic tournament. We empirically study the impact of interim rank on risk taking and performance using data on professionals competing in tournaments for large ...
Mario Pagliero, Christos Genakos
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source