Results 91 to 100 of about 7,108,839 (358)

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

A clinical case of reverse left ventricular remodeling in patient with pathogenic TTN mutation. Case report [PDF]

Терапевтический архив
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death, and heart transplantation in young patients. The causes of DCM are varied and include genetic factors and metabolic, infectious, toxic and others factors. Today it is
Svetlana N. Nasonova, Aleksei N. Meshkov, Igor V. Zhirov, Yulia F. Osmolovskaya, Anastasiia A. Shoshina, Alan V. Gagloev, Irina H. Dzhumaniiazova, Elena A. Zelenova, Veronika V. Erema, Mariia S. Gusakova, Mikhail V. Ivanov, Mikhail V. Terekhov, Daria A. Kashtanova, Alexsandra I. Nekrasova, Sergey I. Mitrofanov, Andrey S. Shingaliev, Vladimir S. Yudin, Anton A. Keskinov, Nataliya V. Gomyranova, Uliana V. Chubykina, Marat V. Ezhov, Sergey N. Tereshchenko, Sergey M. Yudin, Sergey A. Boytsov   +23 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Quantitative Analysis of Muscarinic Antagonist Atropine and Tiotropium in Microvolume Plasma Using Liquid Chromatography–Mass Spectrometry: Application for Pharmacokinetic Studies

Journal of Analytical Methods in Chemistry
Despite the availability of current resources, the development of medical countermeasures remains crucial in combatting the threat posed by chemical warfare agents, such as organophosphorus compounds (OPs), which are toxic nerve agents requiring rapid ...
Marilène Trancart, Mylène Penot, Gwladys Meesemaecker, Romain Boffy, Anne-Sophie Hanak, André-Guilhem Calas, Nicolas Taudon   +6 more
doaj   +1 more source

Lower risk but high risk

Hematology, 2021
Abstract Risk stratification is crucial to the appropriate management of most cancers, but in patients with myelodysplastic syndromes (MDS), for whom expected survival can vary from a few months to more than a decade, accurate disease prognostication is especially important. Currently, patients with MDS are often grouped into higher-risk
openaire   +3 more sources

Superintelligence as a Cause or Cure for Risks of Astronomical Suffering [PDF]

, 2017
Discussions about the possible consequences of creating superintelligence have included the possibility of existential risk, often understood mainly as the risk of human extinction. We argue that suffering risks (s-risks) , where an adverse outcome would
Gloor, Lukas, Sotala, Kaj
core  

Failure dynamics of the global risk network [PDF]

, 2015
Risks threatening modern societies form an intricately interconnected network that often underlies crisis situations. Yet, little is known about how risk materializations in distinct domains influence each other.
Asztalos, Andrea, Lin, Xin, Sreenivasan, Sameet, Szymanski, Boleslaw K.   +3 more
core   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Analysis of potential risk factors associated with urolithiasis [PDF]

, 2022
Erik Drabiščák, Erik Dorko, Marek Vargovčák, Ľubomír Velk, Kvetoslava Rimárová, Štefánia Andraščíková, Viliam Knap   +6 more
openalex   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source