Results 121 to 130 of about 2,993,677 (303)
Aspects of competing risks survival analysis [PDF]
This thesis is focused on the topic of competing risks survival analysis. The first chapter provides an introduction and motivation with a brief literature review.
Bond, Simon James
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cholera amid the climate crisis: a systematic review of flooding-driven health risks in West Africa
Discover Public HealthIntroduction Flooding, a major climate-related disaster, poses a growing threat to public health in West Africa. Frequent and severe rainfall, coupled with poor infrastructure and weak sanitation systems, has worsened the spread of cholera and other ...
Miracle Ayomikun Adesina +7 more
doaj +1 more source
Competing-risks regression in Stata 11 [PDF]
Competing-risks survival regression provides a useful alternative to Cox regression in the presence of one or more competing risks. For example, say that you are studying the time from initial treatment for cancer to recurrence of cancer in relation to ...
Roberto G. Gutierrez
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Revista Gerencia de Riesgos y Seguros (nueva época): Número 171 - junio 2022
, 2022 MAPFRE Global Risks
core +1 more source
Special Issue about Competing Risks and Multi-State Models [PDF]
There is a clear growing interest, at least in the statistical literature, in competing risks and multi-state models. With the rising interest in competing risks and multi-state models a number of software packages have been developed for the analysis of
Hein Putter
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Global record-shattering breadbasket droughts emerge from moderately extreme regional events
Nature CommunicationsSimultaneous droughts across multiple maize-producing regions can strike record-shattering portions of the global maize agricultural area, threatening global food security as the system is poorly adapted to large shocks.
Ji Li +2 more
doaj +1 more source