Results 181 to 190 of about 14,156,764 (395)

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Journal of the American Medical Association (JAMA), 2017
Karoline B. Kuchenbaecker, J. Hopper, D. Barnes, K. Phillips, T. Mooij, M. Roos-Blom, Sarah Jervis, F. V. van Leeuwen, R. Milne, N. Andrieu, D. Goldgar, M. Terry, M. Rookus, D. Easton, A. Antoniou, L. McGuffog, D. G. Evans, D. Barrowdale, D. Frost, J. Adlard, K. Ong, L. Izatt, M. Tischkowitz, R. Eeles, R. Davidson, Shirley V. Hodgson, Steve Ellis, C. Noguès, C. Lasset, D. Stoppa-Lyonnet, J. Fricker, Laurence Faivre, P. Berthet, M. Hooning, L. E. van der Kolk, C. Kets, M. Adank, Esther M. John, Wendy K. Chung, I. Andrulis, M. Southey, M. Daly, S. Buys, A. Osorio, C. Engel, K. Kast, Rita K Schmutzler, T. Caldés, A. Jakubowska, Jacques Simard, Michael L Friedlander, Sue-Anne McLachlan, E. Macháčková, L. Foretova, Y. Tan, Christian F. Singer, E. Oláh, A. Gerdes, B. Arver, H. Olsson   +59 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Risks of Plastic Debris: Unravelling Fact, Opinion, Perception, and Belief

, 2017
Albert A. Koelmans, Ellen Besseling, E.M. Foekema, Merel Kooi, Svenja M. Mintenig, Bernadette C. Ossendorp, Paula E. Redondo‐Hasselerharm, Anja Verschoor, Annemarie P. van Wezel, Marten Scheffer   +9 more
openalex   +1 more source

Intensive Dose-Dense Compared With Conventionally Scheduled Preoperative Chemotherapy for High-Risk Primary Breast Cancer [PDF]

, 2009
Michael Untch, Volker Möbus, Walther Kuhn, B. R. Muck, Christoph Thomssen, Ingo Bauerfeind, Nadia Harbeck, Christoph Werner, Annette Lebeau, Andreas Schneeweiß, S. Kahlert, Franz Koch, Karl Ulrich Petry, D. Wallwiener, R. Kreienberg, Ute‐Susann Albert, Hans‐Joachim Lück, Axel Hinke, F. Jänicke, Gottfried E. Konecny   +19 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Risk Associated With Complications and Mortality After Urgent Surgery vs Elective and Emergency Surgery

, 2017
Matthew G. Mullen, Alex D. Michaels, J. Hunter Mehaffey, Christopher A. Guidry, Florence E. Turrentine, Traci L. Hedrick, Charles M. Friel   +6 more
openalex   +2 more sources

Maternal Periconceptional Alcohol Consumption and Risk of Orofacial Clefts [PDF]

, 2007
Paul A. Romitti, Lin Sun, Margaret A. Honein, Jennita Reefhuis, Adolfo Correa, Sonja A. Rasmussen, the National Birth Defects Prevention Study   +6 more
openalex   +1 more source

Risks for the Long Run: A Potential Resolution of Asset Pricing Puzzles

, 2000
Ravi Bansal, A. Yaron
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source