Results 61 to 70 of about 40,760 (162)

Reduced Mortality in COVID‐19 Patients Treated With Inhaled Extracellular Vesicles Expressing CD24

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Background: Severe COVID‐19, and other systemic infections, can trigger hyperinflammation leading to lung injury. EXO‐CD24, an inhaled extracellular vesicle therapy with anti‐inflammatory properties, has shown acute clinical benefit, but long‐term effects on survival remain unknown.
Shiran Shapira, Guy Vishnevsky, Hadas Yaakobi, Gil Shenberg, Mays Motlaq, Eliezer Liberman, Aminadav Kalisky, Gadi Benari, Sotirios Tsiodras, Nimrod Adi, Jan Lötvall, Nadir Arber   +11 more
wiley   +1 more source

Pharmacokinetic analysis of placental transfer of ritonavir as a component of paxlovid using microdialysis in pregnant rats

Heliyon
Background: Ritonavir is one of the most potent CYP3A4 inhibitor currently on the market, and is often used together with other antiviral drugs to increase their bioavailability and efficacy.
Chung-Kai Sun, Wan-Hsin Lee, Muh-Hwa Yang, Tung-Hu Tsai   +3 more
doaj   +1 more source

Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety?

Journal of Virus Eradication, 2018
Background: Higher plasma tenofovir concentrations are associated with higher risks of renal and bone adverse events. The pharmacokinetic boosters ritonavir (RTV) and cobicistat (COBI) significantly increase plasma area under the curve (AUC ...
Andrew Hill, Sophie L. Hughes, Dzintars Gotham, Anton L. Pozniak   +3 more
doaj   +1 more source

Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway

Toxics
Ritonavir (RTV) is an antiviral and a component of COVID-19 treatments. Moreover, RTV demonstrates anti-cancer effects by suppressing AKT. However, RTV has cytotoxicity and suppresses sperm functions by altering AKT activity.
Eun-Ju Jung, Jae-Hwan Jo, Claudine Uwamahoro, Seung-Ik Jang, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae, Woo-Sung Kwon   +7 more
doaj   +1 more source

A Novel System for Crystal Polymorph Discovery via Selective-Wavelength Infrared Irradiation Using Metamaterials

Crystals
The control of crystal polymorphs is central to the design of pharmaceuticals and functional materials. Conventionally, crystal polymorph production has been controlled primarily by adjusting chemical and thermodynamic parameters.
Yoshio Kondo, Tsuyoshi Totani, Satoru Odashima, Daiki Kato, Norimitsu Tohnai   +4 more
doaj   +1 more source

Ritonavir and bull’s eye maculopathy: case report [Ritonavir und „Bull’s Eye“-Retinopathie: Fallbericht]

GMS Ophthalmology Cases, 2013
[english] Objective: To report on a case of retinal pigment epithelium (RPE) toxicity apparently associated with ritonavir.Methods: We describe a case of gradual-onset blurry vision in both eyes in a 30-year-old HIV-positive male on Highly-Active ...
Santos, Luisa, Ornelas, Conceição, Oliveira Afonso, Cláudia, Vila-Franca, Marta, Pinto, Rita   +4 more
doaj   +1 more source

Nirmatrelvir/Ritonavir Utilization for the Treatment of Non-hospitalized Adults with COVID-19 in the National Veterans Affairs (VA) Healthcare System

Infectious Diseases and Therapy
Introduction Limited data exist regarding real-world utilization of nirmatrelvir/ritonavir. We identified predictors of nirmatrelvir/ritonavir use among Veterans Affairs (VA) outpatients nationally. Methods We conducted a retrospective cohort study among
Haley J. Appaneal, Kerry L. LaPlante, Vrishali V. Lopes, Catherine Martin, Laura Puzniak, Timothy L. Wiemken, Evan J. Zasowski, John M. McLaughlin, Aisling R. Caffrey   +8 more
doaj   +1 more source

Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials

Clinical Pharmacology: Advances and Applications, 2021
Marit Vermunt,1 Serena Marchetti,2 Jos Beijnen1,3,4 1Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam 1066, CX, the Netherlands; 2Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam 1066,
Vermunt M, Marchetti S, Beijnen J
doaj  

Efficacy and safety of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin in treatment of patients with chronic hepatitis C in the Republic of Srpska: A real-life study [PDF]

Scripta Medica, 2019
Background: The purpose of this study was to assess the antiviral efficacy and safety of the direct-acting antivirals (DAAs) in therapy of chronic hepatitis C virus (HCV) infection.
Verhaz Antonija, Kezić Zdravka, Stojiljković Miloš P., Škrbić Ranko   +3 more
doaj  

Minor Contribution of UGT1A1 Inhibition to Atazanavir‐Related Bilirubin Elevation Supported by Conservative PBPK Modeling and Clinical Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 583-586, March 2026.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source