Results 31 to 40 of about 3,443,292 (311)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Stream Assessments and Water Quality Monitoring in the Cocheco River Watershed 2001 Project [PDF]
, 2002 The purpose of the project is to gather data and information through volunteer water quality monitoring and stream surveys in the Cocheco River watershed.
Cocheco River Watershed Coalition
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
, 2019 In the AdS$_3$/CFT$_2$ correspondence, physical interest attaches to understanding Virasoro conformal blocks at large central charge and in a kinematical regime of large Lorentzian time separation, $t\sim c$.
Kraus, Per +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Support for the 3rd Annual Exeter River Alewife Festival [PDF]
, 2003 With support from the NH Estuaries Project (NHEP), the Exeter River Local Advisory Committee (ERLAC) held the 3rd Annual Exeter River Alewife Festival on May 31, 2003 in downtown Exeter.
Exeter River Local Advisory Committee
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2005 On June 5, 2004, the Exeter River Local Advisory Committee (ERLAC) held the 4th Annual Exeter River Alewife Festival along the banks of the Squamscott River in downtown Exeter. Over three dozen organizations exhibited at the Festival and event organizers
Exeter River Local Advisory Committee
core +1 more source
Seasonal behaviour of tidal damping and residual water level slope in the Yangtze River estuary: identifying the critical position and river discharge for maximum tidal damping [PDF]
, 2019 As a tide propagates into the estuary, river discharge affects tidal damping, primarily via a friction term, attenuating tidal motion by increasing the quadratic velocity in the numerator, while reducing the effective friction by increasing the water ...
Cai, Huayang +7 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source