Results 51 to 60 of about 4,473,446 (350)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Support for the 3rd Annual Exeter River Alewife Festival [PDF]

, 2003
With support from the NH Estuaries Project (NHEP), the Exeter River Local Advisory Committee (ERLAC) held the 3rd Annual Exeter River Alewife Festival on May 31, 2003 in downtown Exeter.
Exeter River Local Advisory Committee
core   +2 more sources

Reduced sediment transport in the Yellow River due to anthropogenic changes

, 2016
The erosion, transport and redeposition of sediments shape the Earth's surface, and affect the structure and function of ecosystems and society(1,2). The Yellow River was once the world's largest carrier of fluvial sediment, but its sediment load has ...
Shuai Wang, B. Fu, S. Piao, Y. Lü, P. Ciais, Xiaoming Feng, Yafeng Wang   +6 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Study on the motion characteristics of bedload sediment particles under different sediment transport intensities

River
Bedload studies at the particle scale may help grasp the essence of the problem. Existing studies suffer from short filming durations, limited data volume, and a narrow range of sediment transport intensity variations.
Chunjing Liu, Lingfeng Zhang, Yu Zhang, Xiaopeng Jiang, Fei Liu, Leilei Gu, Jing Lu   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Three‐dimensional characterization of particle morphology in natural gravel and blasted rock fragments using SfM‐MVS photogrammetry

River
This study aims to develop a high‐precision and cost‐efficient method for the three‐dimensional reconstruction of large particles in natural gravel and blasted rock fragments, utilizing Structure from Motion (SfM) and Multi‐View Stereo (MVS) techniques ...
Hongchen Liu, Zitao Zhang, Huaizhi Su, Xuedong Zhang, Jing Hu   +4 more
doaj   +1 more source

Sharing a River [PDF]

Journal of Economic Theory, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ambec, Stefan, Sprumont, Yves
openaire   +6 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The grain size distribution function of suspended load in the lower Yellow River

River
The log‐normal distribution function (LNDF) and Weibull cumulative density function (WCDF) represent two prevalent approaches for characterizing sediment grain size distributions.
Zipu Ma
doaj   +1 more source