Results 151 to 160 of about 667,572 (309)
A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis
Animal Models and Experimental Medicine, EarlyView.A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu +6 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley +1 more source
Archaeological Prospection, EarlyView.ABSTRACT This study presents a strong framework for the detection and classification of Submerged Cultural Heritage Assets (SCHA) in shallow marine environments using the integration of multibeam echosounder and airborne LiDAR bathymetry with object‐based image analysis and fuzzy logic–based classification.
Łukasz Janowski +4 more
wiley +1 more source
NUMERICAL MODELING OF ICE JAM FORMATION IN THE WŁOCŁAWEK RESERVOIR
TASK Quarterly, 2011 Ice jam formation in a run-of-the-river reservoir and the effects of ice jam on water levels and water velocity were simulated using a two-dimensional model for simulating river ice dynamics (DynaRICE).
TOMASZ KOLERSKI
doaj
Ice and Ice Forces in Small Steep Rivers
, 2023 English summary Given the right circumstances ice can wreak havoc on riverine infrastructure. Ice runs pushing ice floes against bridge piers is frequently the governing design condition for bridges in cold regions. The physics of these interactions are complex and forces are hard to predict.
openaire +1 more source
Archaeological Prospection, EarlyView.ABSTRACT Neolithic long barrows are among the earliest monumental structures in Europe, yet in many parts of Central Europe their surface expression has been largely erased by long‐term agricultural activity. This study evaluates the potential of integrated remote sensing approaches for identifying and contextualizing long barrows and associated ...
Petr Krištuf +5 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin +15 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia +3 more
wiley +1 more source
BMEMat, EarlyView.ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning +10 more
wiley +1 more source