Results 81 to 90 of about 667,572 (309)

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Quaternary rupture of a crustal fault beneath Victoria, British Columbia, Canada [PDF]

, 2017
The seismic potential of crustal faults within the forearc of the northern Cascadia subduction zone in British Columbia has remained elusive, despite the recognition of recent seismic activity on nearby fault systems within the Juan de Fuca Strait.
Amos, Colin, Leonard, Lucinda J., Levson, Vic, Morell, Kristin D., Regalla, Christine   +4 more
core   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Mineral precipitation in north slope aufeis [PDF]

The Canning and Shaviovik river aufeis fields were studied on the ground and with aircraft data. Powdered calcium carbonate (CaCO3) patches, a few cm in thickness, were found in discrete locations on both aufeis fields.
Hall, D. K.
core   +1 more source

Permafrost hydrology in changing climatic conditions: seasonal variability of stable isotope composition in rivers in discontinuous permafrost [PDF]

, 2015
Role of changing climatic conditions on permafrost degradation and hydrology was investigated in the transition zone between the tundra and forest ecotones at the boundary of continuous and discontinuous permafrost of the lower Yenisei River.
Nyland, Kelsey E., Opel, Thomas, Shiklomanov, Alexander I., Shiklomanov, Nikolay I., Streletskaya, Irina D., Streletskiy, Dmitry A., Tananaev, Nikita I., Tokarev, Igor   +7 more
core   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

The Dynamic Monitoring of River-Ice Thickness on the Qinghai–Tibet Plateau: Four-Dimensional Structure-from-Motion Photogrammetry

Remote Sensing
River-ice, a significant element of the cryosphere, plays a crucial role in hydrological processes. However, the effectiveness of current river-ice monitoring techniques on the Qinghai–Tibet Plateau is limited due to the complex interplay of ...
Yanwei Fan, Yao Zhang, Junfeng Liu, Rensheng Chen, Zijie Lyu, Lei Wang, Xinmao Ao   +6 more
doaj   +1 more source

The Influence Of The Hydraulic Exchange Relations In The Evolution Of Ice Jam Phenomena On Bistriţa River In The Area Between Dorna Arini (Suceava County) And Borca (Neamţ County)

Present Environment and Sustainable Development, 2015
The presence on Bistriţa River, in identical climatic conditions, of sectors with well-developed ice formations in the immediate vicinity of river sectors lacking or with weakly developed such formations demonstrates the existence of other factors beside
Claudiu Gaman
doaj   +1 more source

Remote sensing of snow and ice: A review of the research in the United States 1975 - 1978 [PDF]

Research work in the United States from 1975-1978 in the field of remote sensing of snow and ice is reviewed. Topics covered include snowcover mapping, snowmelt runoff forecasting, demonstration projects, snow water equivalent and free water content ...
Rango, A.
core   +1 more source

Neoglacial cooling culminates in rapid sea ice oscillations in eastern Fram Strait [PDF]

, 2011
EGU2011-407 The spatial and temporal distribution of sea ice in the subpolar North Atlantic is mainly controlled by the advection of warm Atlantic Water via the Norwegian and West Spitsbergen Current in eastern Fram Strait.
Müller, Juliane, Spielhagen, Robert, Stein, Ruediger, Werner, Kirstin   +3 more
core