Results 111 to 120 of about 2,261,242 (253)
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis
Advanced Science, EarlyView.The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui +12 more
wiley +1 more source
Flood prevention on the lower reaches of the Rellow River
, 1990 Proceedings of a congerence in Zhenzhou, China, 1990: Gong Shiyan, Wu Zhiyao: Introduction. Bao Zicheng, Zhang Mingde, Wang Rudiu: Strenghtening of dykes by Warping.
Shiyang, Gong (author) +1 more
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Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source
An Evaluation of Low‐Cost Terrestrial Lidar Sensors for Assessing Hydrogeomorphic Change
Earth and Space ScienceAccurate topographic data acquired at appropriate spatio‐temporal resolution is often the cornerstone of geomorphic research. Recent decades have seen advances in our ability to generate highly accurate topographic data, primarily through the application
M. T. Perks +4 more
doaj +1 more source
River Dart Biological Survey 10th June - 15th July 1968
, 1968 This is the River Dart Biological Survey from 10th June to 15th July 1968 by the Devon River Authority. This survey was undertaken to investigate the invertebrate bottom fauna of the river and to assess the condition of the river with regard to pollution.
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Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Trinity River Basin Master Plan [PDF]
, 2007 TextThis Master Plan for the Trinity River Basin succeeds and updates a series of documents promulgated by the Trinity River Authority over the past 50 years.
Trinity River Authority
core +1 more source
, 2010 OKACOM's Transboundary Diagnostic Analysis study used integrated flows analysis to develop scenarios for possible developments in the Okavango River Basin.
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Magnetic Water Cleaning of Estrogens via Tight yet Dynamic Binding to Nanoparticles
Advanced Science, EarlyView.Micropollution is one of the big challenges humanity faces with estrogen hormones being emerging pollutants of concern. Here, a supramolecular design strategy is presented that generates a simple nano‐adsorbent material to magnetically remove low‐concentrated estrogens from water.
Lukas Müller +25 more
wiley +1 more source