Results 111 to 120 of about 1,106,375 (305)

Paving the Way to Elucidate Hg's Role in Tumorigenesis

open access: yesAdvanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li   +10 more
wiley   +1 more source

Abiotic Typology of the Rivers and Lakes of the Ukrainian Section of the Western Bug River Basin and its Comparison with Results of Polish Investigations [PDF]

open access: yes, 2019
The completed investigation, which are based on the requirements of the EU WFD and rivers typology systems adapted in Ukraine and Poland, allowed us to identify: for the Western Bug river basin within Ukraine 9 abiotic river types, within Poland – 7.
Grebin, Vasyl V.   +2 more
core  

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

Children of same-sex couples in the United Kingdom [PDF]

open access: yes, 2008
To further develop an understanding of psychological and social functioning of children raised by lesbian couples, the current investigation compared 18 students ages 12 through 16 raised in families led by female same-sex couples who were identified ...
Noret, N, Poteat, V P, Rivers, I
core  

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

open access: yesAdvanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia   +5 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Indigenous challenges to enhance freshwater governance and management in Aotearoa New Zealand - the Waikato river settlement [PDF]

open access: yes, 2010
Co-management of environmental resources is an idea that has been developing for some time in Aotearoa New Zealand as a strategy that recognises Indigenous interests in the environment, and the different ways that people view the world.
Te Aho, Linda
core   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

open access: yesAdvanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao   +18 more
wiley   +1 more source

The effects of precipitation chemistry and catchment area lithology on the quality of river water in selected catchments in eastern Australia [PDF]

open access: yes, 1968
The results of partial chemical analyses of precipitation and river water samples from north-east Queensland and south-eastern New South Wales are presented. Comparisons of water quality in the two areas are made using ionic ratios.
Douglas, Ian
core   +1 more source

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