Results 221 to 230 of about 2,134,823 (333)

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

River plastic hotspot detection from space. [PDF]

iScience
Pérez-García Á, Amanda G, López JF, Rußwurm M, van Emmerik THM.   +4 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Species-Specific Responses to Paleoclimatic Changes and Landscape Barriers Drive Contrasting Phylogeography of Co-Distributed Lemur Species in Northeastern Madagascar. [PDF]

Mol Ecol
van Elst T, Schüßler D, Rafamantanantsoa SM, Radriarimanga T, Rabemananjara NR, Rasolofoson DW, Randimbiharinirina RD, Hohenlohe PA, Radespiel U.   +8 more
europepmc   +1 more source

Blackening and odorization of urban rivers: a bio‐geochemical process

FEMS Microbiology Ecology, 2018
Zhiwei Liang, M. Siegert, Wenwen Fang, Yu Sun, F. Jiang, Hui Lu, Guang-hao Chen, Shanquan Wang   +7 more
semanticscholar   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Bronchiolo-arterial fistula management in a patient with Loeys-Dietz syndrome using a multidisciplinary approach. [PDF]

J Surg Case Rep
Otley M, Kheder M, Wood J, Lightfoot C, Rivers-Bowerman M, Castonguay M, French D.   +6 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Effects of acid mine drainage from collapsed tailings dam on Zambia's human riparian communities: a fuzzy cognitive model perspective. [PDF]

Sci Rep
Nyirenda VR, Chama L, Phiri D, Musuka CG, Simuchimba G, Chibesa M, Simwanda M, Siamujompa M, Kasubika R, Kapembwa S, Siachoono S, Lwali AC, Namukonde N, Nyirenda W, Chunda-Mwango N, Kikamba E, Phiri CJ, M'doma B, Nkhata BA, Mubemba B, Murayama Y.   +20 more
europepmc   +1 more source