Results 31 to 40 of about 1,222,932 (294)
Remotely sensed rivers in the Anthropocene: state of the art and prospects
The rivers of the world are undergoing accelerated change in the Anthropocene, and need to be managed at much broader spatial and temporal scales than before. Fluvial remote sensing now offers a technical and methodological framework that can be deployed
H. Piégay +9 more
semanticscholar +1 more source
The existence of solutions describing the turbulent flow in rivers is proven. The existence of an associated invariant measure describing the statistical properties of this one-dimensional turbulence is established. The turbulent solutions are not smooth but Hölder continuous with exponent 3 / 4 3/4
openaire +3 more sources
The study assessed traditional perceptions of climate change phenomenon influencing adaptation decision and responses among rural women crop farmers in southern Nigeria.
Chinwoke Clara Ifeanyi-obi +3 more
doaj +4 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Considerable attention has been paid to postsecondary students’ higher-order skill development, which has students, parents, employers, and politicians questioning the value of a university degree. Agreement over an essential common core of knowledge or
Alana Hoare +3 more
doaj +1 more source
The Weapons Identification Task: Recommendations for adequately powered research. [PDF]
This article synthesizes the extant literature on the Weapons Identification Task (WIT), a sequential priming paradigm developed to investigate the impact of racial priming on identification of stereotype-congruent and stereotype-irrelevant objects ...
Andrew M Rivers
doaj +1 more source
Multimodal Gestalts and Post-pandemic Utopianism: Drum and Bass on the Bike
Framed within a society insidiously damaged by the novel coronavirus pandemic and associated lockdown restrictions, this article examines the drum and bass on the bike initiative of British DJ Dom Whiting.
Damian J. Rivers
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source

