Results 31 to 40 of about 1,106,375 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Vortex Production at Phase Transitions in Nonrelativistic and Relativistic Media [PDF]

, 1995
We examine string (vortex) formation at a quench for a weakly-coupled global U(1) theory when the excitation spectrum is non-relativistic. It is so similar to vortex production in the corresponding relativistic plasma as to reinforce arguments for the ...
Rivers, R. J.
core   +1 more source

Multimodal Gestalts and Post-pandemic Utopianism: Drum and Bass on the Bike

Frontiers in Communication, 2022
Framed within a society insidiously damaged by the novel coronavirus pandemic and associated lockdown restrictions, this article examines the drum and bass on the bike initiative of British DJ Dom Whiting.
Damian J. Rivers
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Synthesis and Structures of Co Bis-Trifluoromethylpyrazolate Complexes [PDF]

, 2013
Reactions of Co(PMe3)(3)Cl or CoCl2 with 3,5-(CF3)(2)-PzNa in hexane give Co(PMe3)(3)(3,5-(CF3)(2)-Pz) (1) and Co(PMe3)(3)(3,5-(CF3)(2)-Pz)(2) (2) respectively (3,5-(CF3)(2)-PzNa = sodium bis-trifluoromethylpyrazolate).
Jones, Richard A., Rivers, Joseph H.
core   +1 more source

Test Experience, Direct Instruction, and Their Combination Promote Accurate Beliefs about the Testing Effect

Journal of Intelligence, 2023
Practice testing is a highly robust learning strategy that promotes long-term retention, especially in comparison to more passive strategies such as restudying—a finding referred to as the testing effect.
Michelle L. Rivers
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Student Achievement of Institutional Learning Outcomes: Case Study of a Regional University in Western Canada

Canadian Journal for the Scholarship of Teaching and Learning
Considerable attention has been paid to postsecondary students’ higher-order skill development, which has students, parents, employers, and politicians questioning the value of a university degree. Agreement over an essential common core of knowledge or
Alana Hoare, Lorry-Ann Austin, Kimberly Thomas-Francois , Thomas Pypker   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Embedding social innovation and social impact across the disciplines: identifying "Changemaker" attributes [PDF]

, 2015
Purpose—This paper proposes an attributes framework for embedding “Changemaker”—a university initiative for promoting social innovation and social impact—across the disciplines at the University of Northampton.
Alden Rivers, Bethany, Armellini, Alejandro, Nie, Ming   +2 more
core   +1 more source