Results 61 to 70 of about 2,134,823 (333)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Left Heart Changes in Hypertensives Attending Rivers State University Teaching Hospital: An Echocardiographic Review

Ibom Medical Journal
Background: Hypertension, commonly known as high blood pressure, is a significant health challenge globally and in Nigeria, where it stands as the primary cause of cardiovascular diseases.
Ngozi CS, Deinma A, Rita W, Bonas H
doaj   +1 more source

Sharing a River [PDF]

Journal of Economic Theory, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ambec, Stefan, Sprumont, Yves
openaire   +6 more sources

Understanding rivers and their social relations: A critical step to advance environmental water management

WIREs Water, 2019
River flows connect people, places, and other forms of life, inspiring and sustaining diverse cultural beliefs, values, and ways of life. The concept of environmental flows provides a framework for improving understanding of relationships between river ...
E. Anderson, S. Jackson, R. Tharme, M. Douglas, J. Flotemersch, M. Zwarteveen, Chicu Lokgariwar, Mariana Montoya, Alaka Wali, G. Tipa, T. Jardine, J. Olden, Lin Cheng, J. Conallin, B. Cosens, C. Dickens, D. Garrick, D. Groenfeldt, J. Kabogo, D. Roux, A. Ruhí, A. Arthington   +21 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo

Frontiers in Oncology
BackgroundThe FDA’s approval of deutetrabenazine, the first deuterium-labeled drug, demonstrated an improved safety profile compared to its non-deuterated counterpart, tetrabenazine. While Polo-like kinase 1 (PLK1) inhibitors have shown promise in cancer
Tingyan Zhang, Tingyan Zhang, Xiaobing Deng, Haoping Jin, Zhengshu Peng, Zhengshu Peng, Yi-Ching Hsueh, Chunming Zhang, Gang Niu, Gang Niu, Jianfei Yang, Jianfei Yang   +11 more
doaj   +1 more source

Book Review: A Report on Transnational and National Cultural Processes [PDF]

, 1999
A review of Meeting Rivers: A Report on Transnational and National Cultural Processes edited by Lannart ...
Neufeldt, Ronald
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Dynamic Bayesian Nonlinear Calibration [PDF]

, 2014
Statistical calibration where the curve is nonlinear is important in many areas, such as analytical chemistry and radiometry. Especially in radiometry, instrument characteristics change over time, thus calibration is a process that must be conducted as ...
Boone, Edward L., Rivers, Derick L.
core  

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

Arthritis Care &Research, EarlyView.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie, Michael P. Fisher, Kristen Backor, Hannah Tyldsley, Ashira Blazer, Candace Feldman, Andrea Knight, S. Sam Lim, Barbara Ann Polk, Ed Yelin, Edith Williams, Karen H. Costenbader   +11 more
wiley   +1 more source