Results 11 to 20 of about 622,843 (190)

Clinical Pharmacology in the UK, c.1950-2000: Influences and Institutions [PDF]

, 2008
Annotated and edited transcript of a Witness Seminar held on 6 February 2007. Introduction by Dr Mark Walport, The Wellcome Trust.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008.©The Trustee of the Wellcome Trust ...
Reynolds, LA, Tansey, EM
core   +6 more sources

Key learning outcomes for clinical pharmacology and therapeutics education in Europe: A modified Delphi study. [PDF]

, 2022
Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of an uniform high standard.
Michiel A. van Agtmael, Lidwine B. Mokkink, Thierry Christiaens, Romaldas Maciulaitis, Emilio J. Sanz, David J. Brinkman, Jelle Tichelaar, Robert Likic, Simon R. Maxwell, Joao Costa, Milan C. Richir   +10 more
core   +3 more sources

The use of structured assessments, practical skills and performance indicators to assess the ability of pre-registration nursing students to apply the principles of pharmacology and therapeutics to the medication management needs of patients [PDF]

, 2003
This paper discusses how structured assessments, practical skills and performance indicators can be used to assess the ability of pre-registration nursing students’ to analyze and clinically apply the theoretical principles of pharmacology and ...
Banning, M, Maggi Banning, Banning, M.
core   +1 more source

Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement. [PDF]

, 2020
Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of a drug.
Olagunju, Adeniyi, Momper, Jeremiah, Kiser, Jennifer J, Struble, Kimberly, Abrams, Elaine, Colbers, Angela, Best, Brookie M, Cressey, Tim R, Taylor, Graham, Waitt, Catriona, Capparelli, Edmund V, Bekker, Adrie, Mirochnick, Mark, Penazzato, Martina, Eke, Ahizechukwu C, Belew, Yodit, participants of the WHO-IMPAACT workshop on “Approaches to Optimize and Accelerate Pharmacokinetic Studies In Pregnant And Lactating Women”   +16 more
core   +1 more source

Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications [PDF]

, 2020
Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to the analysis of systems biology models ...
채동우
core   +1 more source

Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities

, 2015
Despite advances in biomedical research that have deepened our understanding of cancer hallmarks, resulting in the discovery and development of targeted therapies, the success rates of oncology drug development remain low.
DR Mould, K Venkatakrishnan, Troconiz, I. F., R Bruno, Mehrotra, N., Friberg, Lena E.,, Mould, D. R., Venkatakrishnan, K., IF Trocóniz, Mettetal, J. T., A Stein, Stein, A., N Mehrotra, Ouellet, D., LE Friberg, D Ouellet, Gobburu, J., JT Mettetal, J Gobburu, Bruno, R.   +19 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of NAT2 Using Long-Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies. [PDF]

Clin Pharmacol Ther
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
John S, Boone EC, Yoo B, Ramsey LB, Gaedigk A.   +4 more
europepmc   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source