Results 51 to 60 of about 622,843 (190)

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy [PDF]

, 2019
This white paper presents principles for validating proarrhythmia risk prediction models for regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food and ...
Nave, S, Singer, Thomas, Ni, Haibo, Qu, Z, Nakamura, M, Thomas Singer, Aaron Fullerton, Andrea Greiter‐Wilke, Flora Musuamba Tshinanu, Xin Zhou, Hill, Adam, Fullerton, Aaron, Morotti, Stefano, Musuamba Tshinanu, Flora, Edwards, Andrew G., Holbrook, M, Todd A. Wisialowski, Ridder, Bradley, Ridder, Bradley J., Fullerton, A, Damiano, Bruce, Bueno‐Orovio, A, Zhou, Xin, Mikiko Nakamura, Bueno‐Orovio, Alfonso, Vandenberg, Jamie, Severi, S, Jamie Vandenberg, Wang, Ken, Derek J. Leishman, Liudmila Polonchuk, Xiaomei Han, Clancy, Colleen E, Adam Hill, Clancy, CE, Grandi, Eleonora, Polonchuk, L, Haibo Ni, Tshinanu, Flora Musuamba, Liu, M, Takashi Yoshinaga, Chen, Janell E, Clancy, Colleen E., Andrew G. Edwards, Strauss, David G, Wang, K, Han, Xiaomei, Smith, G, Stockbridge, Norman L, Song, Z, Hill, A, Severi, Stefano, Mirams, Gary, Passini, Elisa, Elisa Passini, Chen, JE, Stefano Severi, Kowey, Peter R., Chen, Janell E., Morotti, S, Peter R. Kowey, Polonchuk, Liudmila, Musuamba Tshinanu, F, Steidl‐Nichols, Jill, Smith, Godfrey, Song, Zhen, Sobie, Eric A., Strauss, DG, Bruce Damiano, Paci, Michelangelo, Zhou, X, Strauss, David G., Michelangelo Paci, Liu, Michael, Leishman, DJ, Mirams, Gary R, Yoshinaga, Takashi, Janell E. Chen, Eric A. Sobie, Li, Zhihua, Kowey, PR, Nave, Stephane, Randall L. Rasmusson, Bueno-Orovio, Alfonso, Blanca Rodriguez, Sobie, Eric A, Nakamura, Mikiko, Gary R. Mirams, Alfonso Bueno‐Orovio, Mirams, GR, Eleonora Grandi, Stephane Nave, Wisialowski, Todd A., Edwards, Andrew G, Han, X, Rasmusson, RL, David G. Strauss, Yoshinaga, T, Stockbridge, Norman L., Michael Liu, Rasmusson, Randall L, Colleen E. Clancy, Rasmusson, Randall L., Stockbridge, NL, Steidl‐Nichols, J, Kowey, Peter R, Edwards, AG, Singer, T, Pierre Morissette, Passini, E, Zhen Song, Rodriguez, Blanca, Rodriguez, B, Vandenberg, J, Greiter‐Wilke, Andrea, Morissette, Pierre, Ridder, Bradley J, Wisialowski, Todd A, Norman L. Stockbridge, Grandi, E, Sobie, EA, Mark Holbrook, Paci, M, Bradley J. Ridder, Damiano, B, Ken Wang, Ni, H, Jill Steidl‐Nichols, Stefano Morotti, Morissette, P, Godfrey Smith, Zhihua Li, Wisialowski, TA, Ridder, BJ, Mirams, Gary R., Qu, Zhilin, Zhilin Qu, Li, Z, Leishman, Derek J, Greiter‐Wilke, A, Leishman, Derek J., Holbrook, Mark   +141 more
core   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Therapeutics Letter 124

, 2019
Therapeutics Letter 124 provides results of the Therapeutics Initiative's fifth readership survey to evaluate perceptions of our academic unit and the impact of Therapeutics Initiative learning events.Medicine, Faculty ofAnesthesiology, Pharmacology and ...
Therapeutics Initiative (University of British Columbia)
core   +1 more source

The 29th Scientific Conference of the Society on NeuroImmune Pharmacology in Omaha, NE, June 8–12, 2025

The 29 th Scientific Conference of the Society on Neuroimmune Pharmacology (SNIP) in Omaha, NE, will occur from June 8 th to 11 th , 2025. This four-day conference showcases world-renowned biomedical research, providing insights into the latest ...
Chang, Linda, Eugenin, Eliseo, Gendelman, Howard E., Roy, Sabita, Fields, Jerel, Booze, Rosemarie M., Andrews, Allison M., Sariyer, IIker K., Booze, Rosemarie, Gorantla, Santhi   +9 more
core   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Clinical pharmacology in the UK, c. 1950–2000: industry and regulation [PDF]

, 2008
Clinical pharmacology in the UK in the 1950s and 1960s was an exciting profession. Many important new drugs were developed and brought to market and a more systematic knowledge of drug effects in humans was needed, as well as ensuring the safety and ...

core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Therapeutics Letter 64

, 2007
Therapeutics Letter 64 provides results of the Therapeutics Initiative's (TI) third readership survey to evaluate perceptions of TI educational activities.Medicine, Faculty ofAnesthesiology, Pharmacology and Therapeutics, Department ofReviewedThe UBC TI ...
Therapeutics Initiative (University of British Columbia)
core   +1 more source