Results 231 to 240 of about 2,524,971 (285)

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos

Advanced Science, EarlyView.
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang, Runbo Li, Ruijie Luo, Qiang Zhang, Zimo Zhao, Haishen Xu, Minglei Zhi, Wenjie Jiang, Meng Wang, Xinze Chen, Zhiqiang Feng, Yingjie Wang, Yuhan Yang, Pengcheng He, Hanyue Su, Tianzhi Chen, Shunxin Wang, Yixuan Yao, Jinghui Yang, Fan Zhao, Tingting Li, Haitao Wang, Xiaosheng Zhang, Jinlong Zhang, Qiuyue Liu, Shuai Gao, Yuchang Yao, Jianyong Han, Suying Cao   +28 more
wiley   +1 more source

Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages. [PDF]

Gut Microbes
Cortés-Martín A, Buttimer C, Maier JL, Tobin CA, Draper LA, Ross RP, Kleiner M, Hill C, Shkoporov AN.   +8 more
europepmc   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

RNA-Seq Analysis Revealed the Virulence Regulatory Network Mediated by the Ferric Uptake Regulator (Fur) in <i>Apostichopus japonicus</i> Pathogenesis Induced by <i>Vibrio splendidus</i>. [PDF]

Microorganisms
Liao C, Hu L, Zhu S, Liang W, Yang L, Li C.   +5 more
europepmc   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

The dynamics of microbiome and virome in migratory birds of southwest China. [PDF]

NPJ Biofilms Microbiomes
Luo Q, Gao H, Xiang Y, Li J, Dong L, Wang X, Liu F, Guo Y, Shen C, Ding Q, Qin C, Liang G, Wen L.   +12 more
europepmc   +1 more source

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China. [PDF]

PLoS One
Lin X, Gong L, Gou Y, Liu Y, Mao S, Chen S, Liu M, Zhu D, Wang M, Jia R, Zhang S, Wu Y, Huang J, Tian B, Yang Q, Zhao X, Cheng A, Ou X.   +17 more
europepmc   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Condensation of the RNA chaperone Hfq is coupled to inhibition of carbon assimilation and contributes to the stabilisation of regulatory RNAs in nitrogen starvedEscherichia coli

McQuail J, Ellis H, Behrends V, Balcells-Nadal C, Bischler T, Gräfenhan T, Wigneshweraraj S.   +6 more
europepmc   +1 more source