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Defining the Inside and Outside of a Catalytic RNA Molecule
Science, 1989Ribozymes are RNA molecules that catalyze biochemical reactions. Fe(II)-EDTA, a solvent-based reagent which cleaves both double- and single-stranded RNA, was used to investigate the structure of the Tetrahymena ribozyme.
Thomas R. Cech, John A. Latham
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Recent insights on RNA folding mechanisms from catalytic RNA
Cellular and Molecular Life Sciences (CMLS), 2000Methods for probing RNA structure in real time have revealed that initial folding steps are complete in less than a second. Refolding of large catalytic RNAs in vitro often results in long-lived intermediates that reach the native structure very slowly.
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Coherent collective modes in catalytic RNA
Zeitschrift f�r Physik B Condensed Matter, 1990We establish the existence ofФ4-solitons travelling along the backbone of an RNA double stranded helix. Taking advantage of the catalytic activity of RNA in proton transfer events, we device a probe for such coherent solitary-wave excitations: We prove that the density of domain walls is increased by the same phonon excitations which would enhance ...
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Antibiotic inhibition of catalytic RNA function
1996A number of compounds inhibit group I intron splicing. Competitive inhibitors include deoxyguanosine, dideoxyguanosine, arginine and streptomycin; the non-competitive inhibitors include members of the aminoglycoside family of antibiotics. Further screening of a collection of antibiotics for their ability to inhibit group I intron splicing identified ...
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Cloning Strategies for Catalytic Antisense RNAs [PDF]
, 2003 Mina Tsagris, Martin Tabler
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Investigating catalytic RNA molecules
Collection Symposium Series, 2002Svetomir B. Tzokov +3 more
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